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- Title
An Italian Prospective Experience on the Association Between Congenital Cytomegalovirus Infection and Autistic Spectrum Disorder.
- Authors
Garofoli, Francesca; Lombardi, Giuseppina; Orcesi, Simona; Pisoni, Camilla; Mazzucchelli, Iolanda; Angelini, Micol; Balottin, Umberto; Stronati, Mauro
- Abstract
The aim of this retrospective study, with prospective data collection, was to correlate congenital cytomegalovirus (CMV) infection with autism spectrum disorder (ASD) and to define its prevalence. Seventy proven congenitally-infected infants, born between 2007 and 2012, were referred to our centre for CMV diagnosis and follow-up, which consisted of a consolidated protocol allowing an early evaluation of autism. We considered four children 2-year old, two of whom, at the age of 3, were diagnosed with ASD demonstrating a 2-3 fold higher prevalence (2.86%), than that in general Italian population (0.66-1.36%).Our protocol enabled us to make the earliest diagnosis and highlight the role of the virus among other causes of autism, which may be a long term sequela of congenital CMV.
- Subjects
ITALY; DIAGNOSIS of autism; AUTISM; CHILD Behavior Checklist; CONFIDENCE intervals; CYTOMEGALOVIRUS diseases; ELECTROENCEPHALOGRAPHY; LONGITUDINAL method; MAGNETIC resonance imaging; NEUROPSYCHOLOGICAL tests; CASE studies; STATISTICAL sampling; VIRAL load; RETROSPECTIVE studies
- Publication
Journal of Autism & Developmental Disorders, 2017, Vol 47, Issue 5, p1490
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-017-3050-3