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- Title
Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy.
- Authors
Shuldiner, Alan R.; O'Connell, Jeffrey R.; Bliden, Kevin P.; Gandhi, Amish; Ryan, Kathleen; Horenstein, Richard B.; Damcott, Coleen M.; Pakyz, Ruth; Tantry, Udaya S.; Gibson, Quince; Pollin, Toni I.; Post, Wendy; Parsa, Afshin; Mitchell, Braxton D.; Faraday, Nauder; Herzog, William; Gurbel, Paul A.
- Abstract
The article focuses on a study which determined the gene variants that influence clopidogrel response. The study included 429 healthy Amish people who underwent genotyping of loss-of-function cytochrome P450 (CYP) 2C19*2 variant (rs4244285). It was designed to analyze the link between CYP 2C19*2 genotype and the clinical effectiveness of clopidogrel therapy. Adenosine diphosphate (ADP)-stimulated platelet aggregation was measured in response to clopidogrel treatment and cardiovascular events. Study authors concluded that CYP 2C19*2 genotype is associated with diminished platelet response to clopidogrel treatment and poor cardiovascular outcomes.
- Subjects
ANTICOAGULANTS; CYTOCHROME P-450; GENES; GENETIC research; ADENOSINE diphosphate; HEALTH outcome assessment
- Publication
JAMA: Journal of the American Medical Association, 2009, Vol 302, Issue 8, p849
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2009.1232