We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Incentive-sensitization and addiction.
- Authors
Robinson, Terry E.; Berridge, Kent C.
- Abstract
The question of addiction concerns the process by which drug-taking behavior, in certain individuals, evolves into compulsive patterns of drug-seeking and drug-taking behavior that take place at the expense of most other activities, and the inability to cease drug-taking, that is, the problem of relapse. In this paper we summarize one view of this process, the "incentive-sensitization" view, which we first proposed in 1993. Four major tenets of the incentive-sensitization view are discussed. These are: (1) potentially addictive drugs share the ability to alter brain organization; (2) the brain systems that are altered include those normally involved in the process of incentive motivation and reward; (3) the critical neuroadaptations for addiction render these brain reward systems hypersensitive ("sensitized") to drugs and drug-associated stimuli; and (4) the brain systems that are sensitized do not mediate the pleasurable or euphoric effects of drugs (drug "liking"), but instead they mediate a subcomponent of reward we have termed incentive salience (drug "wanting").
- Subjects
DRUG abuse; PHARMACODYNAMICS; BRAIN; REWARD (Psychology)
- Publication
Addiction, 2001, Vol 96, Issue 1, p103
- ISSN
0965-2140
- Publication type
Article
- DOI
10.1046/j.1360-0443.2001.9611038.x