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- Title
A SIMPLE MATHEMATICAL MODEL OF NON-SMALL CELL LUNG CANCER INVOLVING MACROPHAGES AND CD8+ T CELLS.
- Authors
LOURENÇO JR., EDGARD; RODRIGUES, DIEGO S.; ANTUNES, MARIA E.; MANCERA, PAULO F. A.; RODRIGUES, GUILHERME
- Abstract
We analyze biological processes interconnected to the tumor microenvironment development of non-small cell lung cancer (NSCLC), considering a proposed ordinary differential equation (ODE) model. The concepts of cancer as a disease, the cellular heterogeneity of the tumor microenvironment composition, and the macrophage cell epigenetic heterogeneity are presented, and the dynamics of the relations between them, the cytotoxic T cells and the neoplasm cells are explored. The apoptosis rate of the macrophage cells which present protumor characteristics is revealed as having a key role in the local stability of the ODE model. Furthermore, the hypothesis on the relevance of the CD8+ T cells in assisting the macrophage cells to control the tumor volume indicates a immunotherapeutic treatment possibility that considers both of these cells effectively.
- Subjects
NON-small-cell lung carcinoma; T cells; CYTOTOXIC T cells; CD8 antigen; ORDINARY differential equations; MATHEMATICAL models
- Publication
Journal of Biological Systems, 2023, Vol 31, Issue 4, p1407
- ISSN
0218-3390
- Publication type
Article
- DOI
10.1142/S021833902350047X