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- Title
Telomere Length Shortening of Peripheral Blood Mononuclear Cells in Solid-Cancer Patients Undergoing Standard-Dose Chemotherapy Might Be Correlated with Good Treatment Response and Neutropenia Severity.
- Authors
Yoon, So Young; Sung, Hwa Jung; Park, Kyong Hwa; Choi, In Keun; Kim, Seok Jin; Oh, Sang Cheul; Seo, Jae Hong; Choi, Chul Won; Kim, Byung Soo; Shin, Sang Won; Kim, Yeul Hong; Kim, Jun Suk
- Abstract
This study evaluated the telomere length changes (ΔTL) of peripheral blood mononuclear cells before and after repetitive standard-dose nonmyeloablative chemotherapy and the association of ΔTL with treatment response and myelosuppression severity. TL was measured with Southern blot analysis in 32 solid-cancer patients without bone marrow metastasis. The mean TL before chemotherapy (t0 TL) and after the 2nd (t1 TL), 4th (t2 TL) and 6th cycle (t3 TL) was 8.49, 8.33, 8.08 and 8.10 kb, respectively. TL became significantly decreased after 4 (p = 0.005) and 6 (p = 0.026) cycles of chemotherapy. The mean value of ΔTL before and after completion of chemotherapy (t0 TL – t3 TL) was 0.46 kb. ΔTL has a significant correlation with good treatment response (r = 0.448, p = 0.005) and the frequency of severe neutropenia (r = 0.417, p < 0.05). Consequently, TL of peripheral blood mononuclear cells was decreased by the repetitive nonmyeloablative standard-dose chemotherapy in solid-cancer patients without bone marrow metastasis, and ΔTL was associated with good treatment response and neutropenia severity. Copyright © 2007 S. Karger AG, Basel
- Subjects
TELOMERES; CHROMOSOMES; CANCER patients; DRUG therapy; BONE marrow; METASTASIS
- Publication
Acta Haematologica, 2007, Vol 118, Issue 1, p30
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000101558