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- Title
Retinal fundus imaging in bipolar disorder: A pilot study.
- Authors
Yusifova, Aygün; Atagün, Murat İ.; Uğurlu, Nagihan; Malekghasemi, Soheil; Şenat, Almila; Demirlek, Cemal; Erel, Özcan
- Abstract
Various brain-imaging techniques, such as arterial spin labeling, perfusion-weighted imaging, positron emission tomography, and single photon emission computed tomography, have determined perfusion abnormalities that are particularly more severe during bipolar disorder (BD) episodes.[1] Retinal fundus imaging is a noninvasive reliable method that can provide information about the cerebral microvascular system.[2] However, few studies have been performed in psychiatric disorders.[[3]] A longitudinal study shows that retinal vascular abnormalities are present in patients with schizophrenia before the onset of the disorder.[3] Venular diameters were enlarged in patients with psychotic symptoms and their first-degree relatives, in comparison to healthy controls (HC).[4] In BD, one study reported no significant difference between BD and HC,[5] whereas another study reported narrowed arterioles and widened venules.[6] Furthermore, another recent study reported that patients with BD had abnormal arteriolar or venular trajectories.[7] Since metabolic problems are common in BD, current results might be confounded by metbolic abnormalities. We could not detect retinal vascular abnormality in patients with BD. Retinal vascular abnormalities in schizophrenia and bipolar disorder: A window to the brain.
- Subjects
BIPOLAR disorder; RETINAL imaging; HYPERPERFUSION; PILOT projects; VASCULAR endothelial growth factors; FIBROBLAST growth factors; DYSLIPIDEMIA
- Publication
Psychiatry & Clinical Neurosciences, 2020, Vol 74, Issue 1, p85
- ISSN
1323-1316
- Publication type
Article
- DOI
10.1111/pcn.12951