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- Title
Melatonin treatment for circadian rhythm sleep disorders.
- Authors
Kamei, Yuichi; Hayakawa, Tatsuro; Urata, Jujiro; Uchiyama, Makoto; Shibui, Kayo; Kim, Keiko; Kudo, Yoshihisa; Okawa, Masako
- Abstract
Abstract This study investigated the effects of melatonin administration on circadian rhythm sleep disorders, and aimed to clarify clinical characteristics of melatonin responders. The subjects were 46 patients with circadian rhythm sleep disorders: 30 Delayed Sleep Phase Syndrome (DSPS) and 16 non-24 h sleep–wake syndrome (non-24). Patients took 0.3–1.0 mg of melatonin 5, 3 and 1 h before habitual bedtime. Seventeen patients responded to melatonin (12 DSPS, five non-24). Comparison of clinical background between responders and non-responders revealed that the responders were characterized by short total sleep time and later onset age of clinical symptoms.
- Subjects
SLEEP disorders; MELATONIN; SLEEP-wake cycle
- Publication
Psychiatry & Clinical Neurosciences, 2000, Vol 54, Issue 3, p381
- ISSN
1323-1316
- Publication type
Article
- DOI
10.1046/j.1440-1819.2000.00724.x