We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Trans-radial approach versus trans-femoral approach in patients with acute coronary syndrome undergoing percutaneous coronary intervention: An updated meta-analysis of randomized controlled trials.
- Authors
Senguttuvan, Nagendra Boopathy; Reddy, Pothireddy M. K.; Shankar, PunatiHari; Abdulkader, Rizwan Suliankatchi; Yallanki, Hanumath Prasad; Kumar, Ashish; Majmundar, Monil; Ramalingam, Vadivelu; Rajendran, Ravindran; Bhoopalan, Kesavamoorthy; Kaliyamoorthy, Dhamodharan; T. R., Muralidharan; Kalra, Ankur; Jayaraj, Ramamoorthi; Ramakrishnan, Sivasubramanian; Daggubati, Ramesh; Thanikachalam, Sadagopan; Seth, Ashok; Bahl, Vinay Kumar
- Abstract
Introduction: Trans-radial approach (TRA) is recommended over trans-femoral approach (TFA) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). We intended to study the effect of access on all-cause mortality. Methods and results: We searched PubMed and EMBASE for randomized studies on patients with ACS undergoing PCI. The primary outcome was all-cause mortality at 30-days. The secondary outcomes included in-hospital mortality, major adverse cardiac or cerebrovascular event (MACE) as defined by the study, net adverse clinical event (NACE), non-fatal myocardial infarction, non-fatal stroke, stent thrombosis, study-defined major bleeding, and minor bleeding, vascular complications, hematoma, pseudoaneurysm, non-access site bleeding, need for transfusion, access site cross-over, contrast volume, procedure duration, and hospital stay duration. We studied 20,122 ACS patients, including 10,037 and 10,085 patients undergoing trans-radial and trans-femoral approaches, respectively. We found mortality benefit in patients with ACS for the trans-radial approach [(1.7% vs. 2.3%; RR: 0.75; 95% CI: 0.62–0.91; P = 0.004; I2 = 0%). Out of 10,465 patients with STEMI, 5,189 patients had TRA and 5,276 had TFA procedures. A similar benefit was observed in patients with STEMI alone [(2.3% vs. 3.3%; RR: 0.71; 95% CI: 0.56–0.90; P = 0.004; I2 = 0%). We observed reduced MACE, NACE, major bleeding, vascular complications, and pseudoaneurysms. No difference in re-infarction, stroke, and serious bleeding requiring blood transfusions were noted. We noticed a small decrease in contrast volume(ml) {mean difference (95% CI): −4.6 [−8.5 to −0.7]}, small but significantly increase in procedural time {mean difference (95% CI) 1.2 [0.1 to 2.3]}and fluoroscopy time {mean difference (95% CI) 0.8 [0.3 to1.4] min} in the trans-radial group. Conclusion: TRA has significantly reduced 30-day all-cause mortality among patients undergoing PCI for ACS. TRA should be the preferred vascular access in patients with ACS.
- Subjects
MYOCARDIAL infarction; ACUTE coronary syndrome; DRUG-eluting stents; PERCUTANEOUS coronary intervention; SURGICAL stents; RANDOMIZED controlled trials; MAJOR adverse cardiovascular events; ARTERIAL catheterization
- Publication
PLoS ONE, 2022, Vol 17, Issue 4, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0266709