We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Hypotensor bioeffect of laser photobiomodulation over intraocular pressure: Noncomparative interventional case review.
- Authors
Rodríguez-Santana, Elizabeth; Santana-Blank, Luis; Santana-Rodriguez, Karin E.
- Abstract
Background Intraocular pressure (IOP) is to date the oniy modifiable risk factor for glaucoma. This paper reports IOP changes in patients with advanced neoplasias treated with an infrared pulsed laser device (IPLD) in a phase I clinical trial and evaluates potential hypotensor bioeffects of the photo-infrared pulsed biomod - ulation (PIPBM) and water oscillator (WO) mechanisms. Study Design Non-comparative interventional case review. Retrospective report. Methods Medical records were selected with the following criteria : At least 1 pre-treatment IOP measurement and 1 TOP measurement 3 months post-TPLD treatment taken within 60 min of the time of initial diurnal measurement using a calibrated Goldmann applanation tonometer ; absence of ocular macro -metastasis, ocular hypertension , glaucoma, previous ocular surgery , or use of steroids , melatonin or topical ocular medication during treatment. Total daily radiant exposure was 4. 5 x 104 J/m2/day (power density 4. 5 x 104 mW/cm2). Main Outcome Measures : Best corrected visual acuity (BCVA) and IOP. Statistical analysis : Student's t test. Results The charts of 5 patients (n = 10 eyes) met selection criteria (45%). Average age :39 (range :25 -59). Sex: 2M (40%), 3 F (60%). A sustained , symmetric IOP drop of 2 mmHg was observed 3 months post -IPLD treatment in OU (P⩽0.0004) remaining under 18 mmHg; no changes were found in BCVA. Conclusion Despite limitations, the clinical and statistical significance of these preliminary data and available mechanistic information suggest an IOP hypotensor effect. Given the clinical safety already documented and the need for effective IOP hypotensor therapies with the neuroprotective and vasoprotective features potentially involved, additional ophthalmic research into PIPBM and WO effects over specific targets appears warranted.
- Subjects
GLAUCOMA; EYE diseases; LASER endoscopy; INTRAOCULAR pressure; CLINICAL trials
- Publication
Journal of Chinese Clinical Medicine, 2011, Vol 6, Issue 4, p1
- ISSN
1562-9023
- Publication type
Article