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- Title
Validation of a Blood-Based Laboratory Test to Aid in the Confirmation of a Diagnosis of Schizophrenia.
- Authors
Schwarz, Emanuel; Izmailov, Rauf; Spain, Michael; Barnes, Anthony; Mapes, James P.; Guest, Paul C.; Rahmoune, Hassan; Pietsch, Sandra; Leweke, F. Markus; Rothermundt, Matthias; Steiner, Johann; Koethe, Dagmar; Kranaster, Laura; Ohrmann, Patricia; Suslow, Thomas; Levin, Yishai; Bogerts, Bernhard; van Beveren, Nico (JM); McAllister, George; Weber, Natalya
- Abstract
We describe the validation of a serum-based test developed by Rules-Based Medicine which can be used to help confirm the diagnosis of schizophrenia. In preliminary studies using multiplex immunoassay profiling technology, we identified a disease signature comprised of 51 analytes which could distinguish schizophrenia (n = 250) from control (n = 230) subjects. In the next stage, these analytes were developed as a refined 51-plex immunoassay panel for validation using a large independent cohort of schizophrenia (n = 577) and control (n = 229) subjects. The resulting test yielded an overall sensitivity of 83% and specificity of 83% with a receiver operating characteristic area under the curve (ROC-AUC) of 89%. These 51 immunoassays and the associated decision rule delivered a sensitive and specific prediction for the presence of schizophrenia in patients compared to matched healthy controls.
- Subjects
SCHIZOPHRENIA; BLOOD serum analysis; IMMUNOASSAY; SENSITIVITY analysis; RULES-Based Medicine Inc.; DIAGNOSIS
- Publication
Biomarker Insights, 2010, Issue 5, p39
- ISSN
1177-2719
- Publication type
Article
- DOI
10.4137/BMI.S4877