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- Title
Low Seroprotection against Preseasonal Influenza Local Strains in Children Might Predict the Upcoming Epidemic Influenza Strains.
- Authors
Wei-Ju Su; Pei-Lan Shao; Ming-Tsan Liu; Ding-Ping Liu; Kuo-Chin Huang; Luan-Yin Chang; Chun-Yi Lu; Jen-Ren Wang; Shin-Ru Shih; Daniel Tsung-Ning Huang; Hsin Chi; Li-Min Huang
- Abstract
Background. Our objective was to determine the serological signals that indicated the possible dominant circulating influenza virus subtypes for the coming influenza seasons. Methods. Healthy children 6 months through 5 years of age, adults 18-60 years of age, and elderly adults >60 years of age were recruited to receive seasonal trivalent inactivated influenza vaccinations from October through December during the 2006-2007 and 2008-2009 seasons. Paired serum samples were collected at baseline and at 3 weeks after vaccination. Using a hemagglutination inhibition (HAI) assay, we measured antibody responses to local influenza strains circulating early in October, before each winter influenza season. Results. A total of 301 subjects were tested for antibody to local strains (80, 120, and 101 subjects in the 2006-2007, 2007-2008, and 2008-2009 seasons, respectively). The dominant winter influenza strains in Taiwan were B/Malaysia/2506/2004-like in the 2006-2007 season, A/Brisbane/59/2007-like virus (H1N1) in the 2007-2008 season, and A/Brisbane/59/2007-like virus (H1N1) in the 2008-2009 season. The group with the lowest number of subjects with an HAI titer of 40 at baseline was children with antibody against the B/Taiwan/0050/2006 in the 2006-2007 season, A/Taiwan/785/2006 (H1N1) in 2007-2008 season, and A/Taiwan/951/2007 (H1N1) in 2008-2009 season. The emergence of these viruses correlated well with the circulating influenza subtype in the following winter peak seasons. Conclusions. Low seroprotection rate among children against a specific locally circulating influenza strain might predict the dominantly circulating subtype of influenza virus in the coming winter season. A year-end preseasonal serological survey of children could provide valuable information about the possible circulating strain and tailor the disease-control strategy accordingly.
- Subjects
TAIWAN; INFLUENZA viruses; INFLUENZA vaccines; SERUM; HEMAGGLUTINATION tests; IMMUNOGLOBULINS; WINTER; INFLUENZA A virus, H1N1 subtype; VOLUMETRIC analysis
- Publication
Clinical Infectious Diseases, 2010, Vol 51, Issue 2, p171
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/653532