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- Title
Morphological parameters associated with neural invasion in oral squamous cell carcinoma.
- Authors
Manjula M.; Priya N. K.; Angadi, Punnya; Seema H.; Alka K.
- Abstract
Context/Background: Neural invasion (NI) is a form of tumor spread distinct from lymphatic and vascular invasion. It has been correlated with aggressive behavior, disease recurrence and increased morbidity and mortality. It has been considered as an independent predictor of poor outcome in several malignancies. Oral squamous cell carcinoma is also a neurotropic malignancy exhibiting varying incidence of NI from 2% to 82%. Despite the importance of NI as a prognostic indicator, the mechanism and associated factors are poorly understood. Aims: To determine morphological parameters associated with neural invasion in oral squamous cell carcinoma. Materials and Methods: Eighty-two archival specimens of patients with primary oral squamous cell carcinoma who underwent surgical excision and radical neck dissection were considered for the study. The presence of neural invasion were analyzed in slides and correlated with clinical as well as morphological parameters such as tumor thickness, tumor grade, pattern of invasion, type of invasive front, type of stroma, lymphovascular invasion, inflammatory response, margin status and lymph node metastasis. Statistical analysis: Univariate and multivariate analysis were used for analysis. Results: Neural invasion was identified in 20 cases (24%) of oral squamous cell carcinoma. Neural invasion was significantly correlated with depth of invasion 45%( 9/20), type of invasive front 30%( 6/20), dense stroma 90% (18/20) and lymphovascular invasion 55%(11/20). Conclusion: Neural invasion was associated with multiple morphological parameters and its identification may have a significant impact on management and prognostic implication of oral squamous cell carcinoma.
- Subjects
ORAL cancer; SQUAMOUS cell carcinoma
- Publication
Journal of Oral & Maxillofacial Pathology (0973029X), 2014, Vol 18, pS112
- ISSN
0973-029X
- Publication type
Abstract