We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Peroxisome protein import: a complex journey.
- Authors
Baker, Alison; Thomas Lanyon Hogg; Warriner, Stuart L.
- Abstract
The import of proteins into peroxisomes possesses many unusual features such as the ability to import folded proteins, and a surprising diversity of targeting signals with differing affinities that can be recognized by the same receptor. As understanding of the structure and function of many components of the protein import machinery has grown, an increasingly complex network of factors affecting each step of the import pathway has emerged. Structural studies have revealed the presence of additional interactions between cargo proteins and the PEX5 receptor that affect import potential, with a subtle network of cargoinduced conformational changes in PEX5 being involved in the import process. Biochemical studies have also indicated an interdependence of receptor-cargo import with release of unloaded receptor from the peroxisome. Here, we provide an update on recent literature concerning mechanisms of protein import into peroxisomes.
- Subjects
PEROXISOMES; PROTEIN analysis; PEROXISOME proliferator-activated receptors; PROTEIN receptors; BIOCHEMICAL research
- Publication
Biochemical Society Transactions, 2016, Vol 44, Issue 3, p783
- ISSN
0300-5127
- Publication type
Article
- DOI
10.1042/BST20160036