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- Title
Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children.
- Authors
Cheng, Yanli; Hao, Guoping; Wang, Xiaohuan; Lu, Haiyan; Wang, Jing; Suo, Taoli; Hou, Zhaohui; Guo, Huimin; Zhang, Shixun
- Abstract
Objective. To investigate the role and mechanism of lncRNA-pvt1 in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). Methods. The expression of lncRNA-pvt1 in bone marrow tissues of ALL patients after initial diagnosis and complete remission was detected by RT-PCR to explore its possible involvement in the pathogenesis of ALL. The proliferation and apoptosis of Jurkat cells transfected with lncRNA-pvt1 were observed by MTT and flow cytometry. Results. lncRNA-pvt1 expression was upregulated in bone marrow of ALL patients. Knockdown of lncRNA-pvt1 inhibited Jurkat cell proliferation and increased its apoptosis rate. Conclusion. Silencing lncRNA-pvt1 expression can inhibit the development of ALL.
- Subjects
LYMPHOBLASTIC leukemia; ACUTE leukemia; BONE marrow; INHIBITION of cellular proliferation; PATHOGENESIS; BONE marrow examination
- Publication
Computational & Mathematical Methods in Medicine, 2022, p1
- ISSN
1748-670X
- Publication type
Article
- DOI
10.1155/2022/8955322