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- Title
Bisphosphonate-related osteochemonecrosis of the jaws.
- Authors
Hegarty, Anne; Georgakopoulou, Eleni; Porter, Stephen
- Abstract
The article provides an update on the adverse effect of bisphosphonate therapy. Bisphosphonates are analogues of inorganic pyrophosphate with a high affinity for hydroxyapatite crystals and uptake into bone, preventing bone resorption. They are poorly absorbed via the intestine and renal excretion occurs without metabolic alteration. Moreover, biphosphonate-related osteochemonecrosis of the jaw comprises necrotic bone in the maxillofacial region.
- Subjects
DIPHOSPHONATES; PYROPHOSPHATES; HYDROXYAPATITE; RESORPTION (Physiology); BONE resorption; EXCRETORY organs
- Publication
British Journal of Hospital Medicine (17508460), 2008, Vol 69, Issue 3, p158
- ISSN
1750-8460
- Publication type
Article
- DOI
10.12968/hmed.2008.69.3.28753