Found: 65

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  • Change in Epigenome-Wide DNA Methylation Over 9 Years and Subsequent Mortality: Results From the InCHIANTI Study.

    Published in:
    2016
    By:
    • Zenobia Moore, Ann;
    • Hernandez, Dena G.;
    • Toshiko Tanaka;
    • Pilling, Luke C.;
    • Nalls, Mike A.;
    • Bandinelli, Stefania;
    • Singleton, Andrew B.;
    • Ferrucci, Luigi;
    • Moore, Ann Zenobia;
    • Tanaka, Toshiko
    Publication type:
    journal article

  • Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction.

    Published in:
    Clinical Epigenetics, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13148-018-0588-7
    By:
    • Ward-Caviness, Cavin K.;
    • Agha, Golareh;
    • Chen, Brian H.;
    • Pfeiffer, Liliane;
    • Wilson, Rory;
    • Wolf, Petra;
    • Gieger, Christian;
    • Schwartz, Joel;
    • Vokonas, Pantel S.;
    • Hou, Lifang;
    • Just, Allan C.;
    • Bandinelli, Stefania;
    • Hernandez, Dena G.;
    • Singleton, Andrew B.;
    • Prokisch, Holger;
    • Meitinger, Thomas;
    • Kastenmüller, Gabi;
    • Ferrucci, Luigi;
    • Baccarelli, Andrea A.;
    • Waldenberger, Melanie
    Publication type:
    Article

  • Heterozygous PRKN mutations are common but do not increase the risk of Parkinson's disease.

    Published in:
    2022
    By:
    • Zhu, William;
    • Huang, Xiaoping;
    • Yoon, Esther;
    • Bandres-Ciga, Sara;
    • Blauwendraat, Cornelis;
    • Billingsley, Kimberly J;
    • Cade, Joshua H;
    • Wu, Beverly P;
    • Williams, Victoria H;
    • Schindler, Alice B;
    • Brooks, Janet;
    • Gibbs, J Raphael;
    • Hernandez, Dena G;
    • Ehrlich, Debra;
    • Singleton, Andrew B;
    • Narendra, Derek P
    Publication type:
    journal article

  • Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.

    Published in:
    Brain: A Journal of Neurology, 2020, v. 143, n. 1, p. 234, doi. 10.1093/brain/awz350
    By:
    • Blauwendraat, Cornelis;
    • Reed, Xylena;
    • Krohn, Lynne;
    • Heilbron, Karl;
    • Bandres-Ciga, Sara;
    • Tan, Manuela;
    • Gibbs, J Raphael;
    • Hernandez, Dena G;
    • Kumaran, Ravindran;
    • Langston, Rebekah;
    • Bonet‐Ponce, Luis;
    • Alcalay, Roy N;
    • Hassin-Baer, Sharon;
    • Greenbaum, Lior;
    • Iwaki, Hirotaka;
    • Leonard, Hampton L;
    • Grenn, Francis P;
    • Ruskey, Jennifer A;
    • Sabir, Marya;
    • Ahmed, Sarah
    Publication type:
    Article

  • Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.

    Published in:
    2019
    By:
    • Blauwendraat, Cornelis;
    • Reed, Xylena;
    • Krohn, Lynne;
    • Heilbron, Karl;
    • Bandres-Ciga, Sara;
    • Tan, Manuela;
    • Gibbs, J Raphael;
    • Hernandez, Dena G;
    • Kumaran, Ravindran;
    • Langston, Rebekah;
    • Bonet-Ponce, Luis;
    • Alcalay, Roy N;
    • Hassin-Baer, Sharon;
    • Greenbaum, Lior;
    • Iwaki, Hirotaka;
    • Leonard, Hampton L;
    • Grenn, Francis P;
    • Ruskey, Jennifer A;
    • Sabir, Marya;
    • Ahmed, Sarah
    Publication type:
    journal article

  • A SINE-VNTR- Alu in the LRIG2 Promoter Is Associated with Gene Expression at the Locus.

    Published in:
    International Journal of Molecular Sciences, 2020, v. 21, n. 22, p. 8486, doi. 10.3390/ijms21228486
    By:
    • Hall, Ashley;
    • Moore, Anni K.;
    • Hernandez, Dena G.;
    • Billingsley, Kimberley J.;
    • Bubb, Vivien J.;
    • Quinn, John P.
    Publication type:
    Article

  • Resolving the polymorphism-in-probe problem is critical for correct interpretation of expression QTL studies.

    Published in:
    Nucleic Acids Research, 2013, v. 41, n. 7, p. e88, doi. 10.1093/nar/gkt069
    By:
    • Ramasamy, Adaikalavan;
    • Trabzuni, Daniah;
    • Gibbs, J. Raphael;
    • Dillman, Allissa;
    • Hernandez, Dena G.;
    • Arepalli, Sampath;
    • Walker, Robert;
    • Smith, Colin;
    • Ilori, Gigaloluwa Peter;
    • Shabalin, Andrey A.;
    • Li, Yun;
    • Singleton, Andrew B.;
    • Cookson, Mark R.;
    • Hardy, John;
    • Ryten, Mina;
    • Weale, Michael E.
    Publication type:
    Article

  • A candidate gene study of genetic risk for dementia and mild cognitive impairment (MCI) in women aged >65 years: Results from the women's health initiative memory study (WHIMS).

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2014, v. 10, p. P787, doi. 10.1016/j.jalz.2014.05.1525
    By:
    • Driscoll, Ira;
    • Snively, Beverly M.;
    • Espeland, Mark A.;
    • Shumaker, Sally A.;
    • Rapp, Stephen R.;
    • Goveas, Joseph S.;
    • Casanova, Ramon;
    • Wactawski-Wende, Jean;
    • Manson, JoAnn E.;
    • Rossom, Rebecca C.;
    • Brooks, Janet;
    • Hernandez, Dena G.;
    • Singleton, Andrew B.;
    • Resnick, Susan M.
    Publication type:
    Article

  • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.

    Published in:
    Nature Genetics, 2014, v. 46, n. 9, p. 989, doi. 10.1038/ng.3043
    By:
    • Nalls, Mike A;
    • Pankratz, Nathan;
    • Lill, Christina M;
    • Do, Chuong B;
    • Hernandez, Dena G;
    • Saad, Mohamad;
    • DeStefano, Anita L;
    • Kara, Eleanna;
    • Bras, Jose;
    • Sharma, Manu;
    • Schulte, Claudia;
    • Keller, Margaux F;
    • Arepalli, Sampath;
    • Letson, Christopher;
    • Edsall, Connor;
    • Stefansson, Hreinn;
    • Liu, Xinmin;
    • Pliner, Hannah;
    • Lee, Joseph H;
    • Cheng, Rong
    Publication type:
    Article

  • Genome-wide association study reveals genetic risk underlying Parkinson's disease.

    Published in:
    Nature Genetics, 2009, v. 41, n. 12, p. 1308, doi. 10.1038/ng.487
    By:
    • Simón-Sánchez, Javier;
    • Schulte, Claudia;
    • Bras, Jose M.;
    • Sharma, Manu;
    • Gibbs, J. Raphael;
    • Berg, Daniela;
    • Paisan-Ruiz, Coro;
    • Lichtner, Peter;
    • Scholz, Sonja W.;
    • Hernandez, Dena G.;
    • Krüger, Rejko;
    • Federoff, Monica;
    • Klein, Christine;
    • Goate, Alison;
    • Perlmutter, Joel;
    • Bonin, Michael;
    • Nalls, Michael A.;
    • Illig, Thomas;
    • Gieger, Christian;
    • Houlden, Henry
    Publication type:
    Article

  • QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration.

    Published in:
    Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-46063-8
    By:
    • Advani, Jayshree;
    • Mehta, Puja A.;
    • Hamel, Andrew R.;
    • Mehrotra, Sudeep;
    • Kiel, Christina;
    • Strunz, Tobias;
    • Corso-Díaz, Ximena;
    • Kwicklis, Madeline;
    • van Asten, Freekje;
    • Ratnapriya, Rinki;
    • Chew, Emily Y.;
    • Hernandez, Dena G.;
    • Montezuma, Sandra R.;
    • Ferrington, Deborah A.;
    • Weber, Bernhard H. F.;
    • Segrè, Ayellet V.;
    • Swaroop, Anand
    Publication type:
    Article

  • Imputation of Variants from the 1000 Genomes Project Modestly Improves Known Associations and Can Identify Low-frequency Variant - Phenotype Associations Undetected by HapMap Based Imputation

    Published in:
    PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0064343
    By:
    • Wood, Andrew R.;
    • Perry, John R. B.;
    • Tanaka, Toshiko;
    • Hernandez, Dena G.;
    • Zheng, Hou-Feng;
    • Melzer, David;
    • Gibbs, J. Raphael;
    • Nalls, Michael A.;
    • Weedon, Michael N.;
    • Spector, Tim D.;
    • Richards, J. Brent;
    • Bandinelli, Stefania;
    • Ferrucci, Luigi;
    • Singleton, Andrew B.;
    • Frayling, Timothy M.
    Publication type:
    Article

  • Genome Wide Assessment of Young Onset Parkinson's Disease from Finland.

    Published in:
    2012
    By:
    • Hernandez, Dena G.;
    • Nalls, Michael A.;
    • Ylikotila, Pauli;
    • Keller, Margaux;
    • Hardy, John A.;
    • Majamaa, Kari;
    • Singleton, Andrew B.
    Publication type:
    Case Study

  • Genomic Risk Profiling of Ischemic Stroke: Results of an International Genome-Wide Association Meta-Analysis.

    Published in:
    PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0023161
    By:
    • Meschia, James F.;
    • Singleton, Andrew;
    • Nalls, Michael A.;
    • Rich, Stephen S.;
    • Sharma, Pankaj;
    • Ferrucci, Luigi;
    • Matarin, Mar;
    • Hernandez, Dena G.;
    • Pearce, Kerra;
    • Brott, Thomas G.;
    • Brown Jr., Robert D.;
    • Hardy, John;
    • Worrall, Bradford B.
    Publication type:
    Article

  • SLC25A46 Mutations Associated with Autosomal Recessive Cerebellar Ataxia in North African Families.

    Published in:
    Neurodegenerative Diseases, 2017, v. 17, n. 4/5, p. 208, doi. 10.1159/000464445
    By:
    • Hammer, Monia B.;
    • Ding, Jinhui;
    • Mochel, Fanny;
    • Eleuch-Fayache, Ghada;
    • Charles, Perrine;
    • Coutelier, Marie;
    • Gibbs, J. Raphael;
    • arepalli, Sampath K.;
    • Chong, Sean B.;
    • Hernandez, Dena G.;
    • Majounie, Elisa;
    • Clipman, Steven;
    • Bouhlal, Yosr;
    • Nehdi, Houda;
    • Brice, alexis;
    • Hentati, Faycal;
    • Stevanin, Giovanni;
    • amouri, Rim;
    • Durr, alexandra;
    • Singleton, andrew B.
    Publication type:
    Article

  • Using DNA Methylation to Understand Biological Consequences of Genetic Variability.

    Published in:
    Neurodegenerative Diseases, 2012, v. 9, n. 2, p. 53, doi. 10.1159/000333097
    By:
    • Hernandez, Dena G.;
    • Singleton, Andrew B.
    Publication type:
    Article

  • Genome-wide association study confirms extant PD risk loci among the Dutch.

    Published in:
    European Journal of Human Genetics, 2011, v. 19, n. 6, p. 655, doi. 10.1038/ejhg.2010.254
    By:
    • Simón-Sánchez, Javier;
    • van Hilten, Jacobus J.;
    • van de Warrenburg, Bart;
    • Post, Bart;
    • Berendse, Henk W.;
    • Arepalli, Sampath;
    • Hernandez, Dena G.;
    • de Bie, Rob M. A.;
    • Velseboer, Daan;
    • Scheffer, Hans;
    • Bloem, Bas;
    • van Dijk, Karin D.;
    • Rivadeneira, Fernando;
    • Hofman, Albert;
    • Uitterlinden, André G.;
    • Rizzu, Patrizia;
    • Bochdanovits, Zoltan;
    • Singleton, Andrew B.;
    • Heutink, Peter
    Publication type:
    Article

  • Genotype, haplotype and copy-number variation in worldwide human populations.

    Published in:
    Nature, 2008, v. 451, n. 7181, p. 998, doi. 10.1038/nature06742
    By:
    • Jakobsson, Mattias;
    • Scholz, Sonja W.;
    • Scheet, Paul;
    • Gibbs, J. Raphael;
    • VanLiere, Jenna M.;
    • Fung, Hon-Chung;
    • Szpiech, Zachary A.;
    • Degnan, James H.;
    • Wang, Kai;
    • Guerreiro, Rita;
    • Bras, Jose M.;
    • Schymick, Jennifer C.;
    • Hernandez, Dena G.;
    • Traynor, Bryan J.;
    • Simon-Sanchez, Javier;
    • Matarin, Mar;
    • Britton, Angela;
    • van de Leemput, Joyce;
    • Rafferty, Ian;
    • Bucan, Maja
    Publication type:
    Article

  • Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease.

    Published in:
    JAMA Neurology, 2018, v. 75, n. 11, p. 1416, doi. 10.1001/jamaneurol.2018.1885
    By:
    • Blauwendraat, Cornelis;
    • Reed, Xylena;
    • Kia, Demis A.;
    • Gan-Or, Ziv;
    • Lesage, Suzanne;
    • Pihlstrøm, Lasse;
    • Guerreiro, Rita;
    • Gibbs, J. Raphael;
    • Sabir, Marya;
    • Ahmed, Sarah;
    • Ding, Jinhui;
    • Alcalay, Roy N.;
    • Hassin-Baer, Sharon;
    • Pittman, Alan M.;
    • Brooks, Janet;
    • Edsall, Connor;
    • Hernandez, Dena G.;
    • Chung, Sun Ju;
    • Goldwurm, Stefano;
    • Toft, Mathias
    Publication type:
    Article

  • Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.

    Published in:
    JAMA Neurology, 2017, v. 74, n. 7, p. 780, doi. 10.1001/jamaneurol.2017.0469
    By:
    • Witoelar, Aree;
    • Jansen, Iris E.;
    • Yunpeng Wang;
    • Desikan, Rahul S.;
    • Gibbs, J. Raphael;
    • Blauwendraat, Cornelis;
    • Thompson, Wesley K.;
    • Hernandez, Dena G.;
    • Djurovic, Srdjan;
    • Schork, Andrew J.;
    • Bettella, Francesco;
    • Ellinghaus, David;
    • Franke, Andre;
    • Lie, Benedicte A.;
    • McEvoy, Linda K.;
    • Karlsen, Tom H.;
    • Lesage, Suzanne;
    • Morris, Huw R.;
    • Brice, Alexis;
    • Wood, Nicholas W.
    Publication type:
    Article

  • A Genome-Wide Association Study of Myasthenia Gravis.

    Published in:
    JAMA Neurology, 2015, v. 72, n. 4, p. 396, doi. 10.1001/jamaneurol.2014.4103
    By:
    • Renton, Alan E.;
    • Pliner, Hannah A.;
    • Provenzano, Carlo;
    • Evoli, Amelia;
    • Ricciardi, Roberta;
    • Nalls, Michael A.;
    • Marangi, Giuseppe;
    • Abramzon, Yevgeniya;
    • Arepalli, Sampath;
    • Sean Chong;
    • Hernandez, Dena G.;
    • Johnson, Janel O.;
    • Bartoccioni, Emanuela;
    • Scuderi, Flavia;
    • Maestri, Michelangelo;
    • Gibbs, J. Raphael;
    • Errichiello, Edoardo;
    • Chiò, Adriano;
    • Restagno, Gabriella;
    • Sabatelli, Mario
    Publication type:
    Article

  • A 6.4 Mb Duplication of the a-Synuclein Locus Causing Frontotemporal Dementia and Parkinsonism Phenotype-Genotype Correlations.

    Published in:
    JAMA Neurology, 2014, v. 71, n. 9, p. 1162, doi. 10.1001/jamaneurol.2014.994
    By:
    • Kara, Eleanna;
    • Kiely, Aoife P.;
    • Proukakis, Christos;
    • Giffin, Nicola;
    • Love, Seth;
    • Hehir, Jason;
    • Rantell, Khadija;
    • Pandraud, Amelie;
    • Hernandez, Dena G.;
    • Nacheva, Elizabeth;
    • Pittman, Alan M.;
    • Nalls, Mike A.;
    • Singleton, Andrew B.;
    • Revesz, Tamas;
    • Bhatia, Kailash P.;
    • Quinn, Niall;
    • Hardy, John;
    • Holton, Janice L.;
    • Houlden, Henry
    Publication type:
    Article

  • Finnish Parkinson's disease study integrating protein-protein interaction network data with exome sequencing analysis.

    Published in:
    Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-55479-y
    By:
    • Siitonen, Ari;
    • Kytövuori, Laura;
    • Nalls, Mike A.;
    • Gibbs, Raphael;
    • Hernandez, Dena G.;
    • Ylikotila, Pauli;
    • Peltonen, Markku;
    • Singleton, Andrew B.;
    • Majamaa, Kari
    Publication type:
    Article

  • Exome sequencing reveals riboflavin transporter mutations as a cause of motor neuron disease.

    Published in:
    Brain: A Journal of Neurology, 2012, v. 135, n. 9, p. 2875, doi. 10.1093/brain/aws161
    By:
    • Johnson, Janel O.;
    • Gibbs, J. Raphael;
    • Megarbane, Andre;
    • Urtizberea, J. Andoni;
    • Hernandez, Dena G.;
    • Foley, A. Reghan;
    • Arepalli, Sampath;
    • Pandraud, Amelie;
    • Simón-Sánchez, Javier;
    • Clayton, Peter;
    • Reilly, Mary M.;
    • Muntoni, Francesco;
    • Abramzon, Yevgeniya;
    • Houlden, Henry;
    • Singleton, Andrew B.
    Publication type:
    Article

  • Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2).

    Published in:
    NPJ Parkinson's Disease, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41531-023-00533-w
    By:
    • Towns, Clodagh;
    • Richer, Madeleine;
    • Jasaityte, Simona;
    • Stafford, Eleanor J.;
    • Joubert, Julie;
    • Antar, Tarek;
    • Martinez-Carrasco, Alejandro;
    • Makarious, Mary B.;
    • Casey, Bradford;
    • Vitale, Dan;
    • Levine, Kristin;
    • Leonard, Hampton;
    • Pantazis, Caroline B.;
    • Screven, Laurel A.;
    • Hernandez, Dena G.;
    • Wegel, Claire E.;
    • Solle, Justin;
    • Nalls, Mike A.;
    • Blauwendraat, Cornelis;
    • Singleton, Andrew B.
    Publication type:
    Article

  • Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease.

    Published in:
    Annals of Neurology, 2021, v. 90, n. 1, p. 35, doi. 10.1002/ana.26090
    By:
    • Blauwendraat, Cornelis;
    • Iwaki, Hirotaka;
    • Makarious, Mary B.;
    • Bandres‐Ciga, Sara;
    • Leonard, Hampton L.;
    • Grenn, Francis P.;
    • Lake, Julie;
    • Krohn, Lynne;
    • Tan, Manuela;
    • Kim, Jonggeol J.;
    • Gibbs, Jesse R.;
    • Hernandez, Dena G.;
    • Ruskey, Jennifer A.;
    • Pihlstrøm, Lasse;
    • Toft, Mathias;
    • Hilten, Jacobus J.;
    • Marinus, Johan;
    • Schulte, Claudia;
    • Brockmann, Kathrin;
    • Sharma, Manu
    Publication type:
    Article

  • Clinical and positron emission tomography of Parkinson's disease caused by LRRK2.

    Published in:
    Annals of Neurology, 2005, v. 57, n. 3, p. 453
    By:
    • Dena G. Hernandez;
    • Coro Paisán‐Ruíz;
    • Aideen McInerney‐Leo;
    • Shushant Jain;
    • Andreas Meyer‐Lindenberg;
    • E. Whitney Evans;
    • Karen F. Berman;
    • Janel Johnson;
    • Georg Auburger;
    • Alejandro A. Schäffer;
    • Grisel J. Lopez;
    • Robert L. Nussbaum;
    • Andrew B. Singleton
    Publication type:
    Article

  • Case-Control study of the extended tau gene haplotype in Parkinson's disease.

    Published in:
    2001
    By:
    • Maraganore, Demetrius M.;
    • Hernandez, Dena G.;
    • Singleton, Andrew B.;
    • Farrer, Matthew J.;
    • McDonnell, Shannon K.;
    • Hutton, Michael L.;
    • Hardy, John A.;
    • Rocca, Walter A.;
    • Maraganore, D M;
    • Hernandez, D G;
    • Singleton, A B;
    • Farrer, M J;
    • McDonnell, S K;
    • Hutton, M L;
    • Hardy, J A;
    • Rocca, W A
    Publication type:
    journal article

  • Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance.

    Published in:
    Journal of Neurochemistry, 2016, v. 139, p. 59, doi. 10.1111/jnc.13593
    By:
    • Hernandez, Dena G.;
    • Reed, Xylena;
    • Singleton, Andrew B.
    Publication type:
    Article

  • Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis.

    Published in:
    Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-68848-9
    By:
    • Gao, Yixin;
    • Wang, Ting;
    • Yu, Xinghao;
    • International FTD-Genomics Consortium (IFGC);
    • Ferrari, Raffaele;
    • Hernandez, Dena G.;
    • Nalls, Michael A.;
    • Rohrer, Jonathan D.;
    • Ramasamy, Adaikalavan;
    • Kwok, John B. J.;
    • Dobson-Stone, Carol;
    • Brooks, William S.;
    • Schofield, Peter R.;
    • Halliday, Glenda M.;
    • Hodges, John R.;
    • Piguet, Olivier;
    • Bartley, Lauren;
    • Thompson, Elizabeth;
    • Haan, Eric;
    • Hernández, Isabel
    Publication type:
    Article

  • Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies.

    Published in:
    Human Molecular Genetics, 2014, v. 23, n. 23, p. 6139, doi. 10.1093/hmg/ddu334
    By:
    • Bras, Jose;
    • Guerreiro, Rita;
    • Darwent, Lee;
    • Parkkinen, Laura;
    • Ansorge, Olaf;
    • Escott-Price, Valentina;
    • Hernandez, Dena G.;
    • Nalls, Michael A.;
    • Clark, Lorraine N.;
    • Honig, Lawrence S.;
    • Marder, Karen;
    • Van Der Flier, Wiesje M.;
    • Lemstra, Afina;
    • Scheltens, Philip;
    • Rogaeva, Ekaterina;
    • St George-Hyslop, Peter;
    • Londos, Elisabet;
    • Zetterberg, Henrik;
    • Ortega-Cubero, Sara;
    • Pastor, Pau
    Publication type:
    Article

  • Genetic comorbidities in Parkinson's disease.

    Published in:
    Human Molecular Genetics, 2014, v. 23, n. 3, p. 831
    By:
    • Nalls, Mike A.;
    • Saad, Mohamad;
    • Noyce, Alastair J.;
    • Keller, Margaux F.;
    • Schrag, Anette;
    • Bestwick, Jonathan P.;
    • Traynor, Bryan J.;
    • Gibbs, J. Raphael;
    • Hernandez, Dena G.;
    • Cookson, Mark R.;
    • Morris, Huw R.;
    • Williams, Nigel;
    • Gasser, Thomas;
    • Heutink, Peter;
    • Wood, Nick;
    • Hardy, John;
    • Martinez, Maria;
    • Singleton, Andrew B.
    Publication type:
    Article

  • Using genome-wide complex trait analysis to quantify ‘missing heritability’ in Parkinson's disease.

    Published in:
    Human Molecular Genetics, 2013, v. 22, n. 14, p. 2973
    By:
    • Keller, Margaux F.;
    • Saad, Mohamad;
    • Bras, Jose;
    • Bettella, Francesco;
    • Nicolaou, Nayia;
    • Simón-Sánchez, Javier;
    • Mittag, Florian;
    • chel, Finja Bü;
    • Sharma, Manu;
    • Gibbs, J. Raphael;
    • Schulte, Claudia;
    • Moskvina, Valentina;
    • Durr, Alexandra;
    • Holmans, Peter;
    • Kilarski, Laura L.;
    • Guerreiro, Rita;
    • Hernandez, Dena G.;
    • Brice, Alexis;
    • Ylikotila, Pauli;
    • Stefánsson, Hreinn
    Publication type:
    Article

  • Using genome-wide complex trait analysis to quantify ‘missing heritability’ in Parkinson's disease.

    Published in:
    Human Molecular Genetics, 2013, v. 22, n. 8, p. 1696
    By:
    • Keller, Margaux F.;
    • Saad, Mohamad;
    • Bras, Jose;
    • Bettella, Francesco;
    • Nicolaou, Nayia;
    • Simón-Sánchez, Javier;
    • Mittag, Florian;
    • Büchel, Finja;
    • Sharma, Manu;
    • Gibbs, J. Raphael;
    • Schulte, Claudia;
    • Moskvina, Valentina;
    • Durr, Alexandra;
    • Holmans, Peter;
    • Kilarski, Laura L.;
    • Guerreiro, Rita;
    • Hernandez, Dena G.;
    • Brice, Alexis;
    • Ylikotila, Pauli;
    • Stefánsson, Hreinn
    Publication type:
    Article

  • Using genome-wide complex trait analysis to quantify ‘missing heritability’ in Parkinson's disease.

    Published in:
    Human Molecular Genetics, 2012, v. 21, n. 22, p. 4996
    By:
    • Keller, Margaux F.;
    • Saad, Mohamad;
    • Bras, Jose;
    • Bettella, Francesco;
    • Nicolaou, Nayia;
    • Simón-Sánchez, Javier;
    • Mittag, Florian;
    • Büchel, Finja;
    • Sharma, Manu;
    • Gibbs, J. Raphael;
    • Schulte, Claudia;
    • Moskvina, Valentina;
    • Durr, Alexandra;
    • Holmans, Peter;
    • Kilarski, Laura L.;
    • Guerreiro, Rita;
    • Hernandez, Dena G.;
    • Brice, Alexis;
    • Ylikotila, Pauli;
    • Stefánsson, Hreinn
    Publication type:
    Article

  • MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies.

    Published in:
    Human Molecular Genetics, 2012, v. 21, n. 18, p. 4094, doi. 10.1093/hmg/dds238
    By:
    • Trabzuni, Daniah;
    • Wray, Selina;
    • Vandrovcova, Jana;
    • Ramasamy, Adaikalavan;
    • Walker, Robert;
    • Smith, Colin;
    • Luk, Connie;
    • Gibbs, J. Raphael;
    • Dillman, Allissa;
    • Hernandez, Dena G.;
    • Arepalli, Sampath;
    • Singleton, Andrew B.;
    • Cookson, Mark R.;
    • Pittman, Alan M.;
    • de Silva, Rohan;
    • Weale, Michael E.;
    • Hardy, John;
    • Ryten, Mina
    Publication type:
    Article

  • Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association.

    Published in:
    Human Molecular Genetics, 2011, v. 20, n. 20, p. 4082, doi. 10.1093/hmg/ddr328
    By:
    • Wood, Andrew R.;
    • Hernandez, Dena G.;
    • Nalls, Michael A.;
    • Yaghootkar, Hanieh;
    • Gibbs, J. Raphael;
    • Harries, Lorna W.;
    • Chong, Sean;
    • Moore, Matthew;
    • Weedon, Michael N.;
    • Guralnik, Jack M.;
    • Bandinelli, Stefania;
    • Murray, Anna;
    • Ferrucci, Luigi;
    • Singleton, Andrew B;
    • Melzer, David;
    • Frayling, Timothy M.
    Publication type:
    Article

  • Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites.

    Published in:
    Clinical Epigenetics, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13148-019-0722-1
    By:
    • Tajuddin, Salman M.;
    • Hernandez, Dena G.;
    • Chen, Brian H.;
    • Noren Hooten, Nicole;
    • Mode, Nicolle A.;
    • Nalls, Mike A.;
    • Singleton, Andrew B.;
    • Ejiogu, Ngozi;
    • Chitrala, Kumaraswamy Naidu;
    • Zonderman, Alan B.;
    • Evans, Michele K.
    Publication type:
    Article

  • GBA1 rs3115534 Is Associated with REM Sleep Behavior Disorder in Parkinson’s Disease in Nigerians.

    Published in:
    Movement Disorders, 2024, v. 39, n. 4, p. 728, doi. 10.1002/mds.29753
    By:
    • Ojo, Oluwadamilola Omolara;
    • Bandres-Ciga, Sara;
    • Makarious, Mary B.;
    • Crea, Peter Wild;
    • Hernandez, Dena G.;
    • Houlden, Henry;
    • Rizig, Mie;
    • Singleton, Andrew B.;
    • Noyce, Alastair J.;
    • Nalls, Mike A.;
    • Blauwendraat, Cornelis;
    • Okubadejo, Njideka Ulunma
    Publication type:
    Article

  • The Interaction between HLA-DRB1 and Smoking in Parkinson's Disease Revisited.

    Published in:
    2022
    By:
    • Domenighetti, Cloé;
    • Douillard, Venceslas;
    • Sugier, Pierre‐Emmanuel;
    • Sreelatha, Ashwin Ashok Kumar;
    • Schulte, Claudia;
    • Grover, Sandeep;
    • May, Patrick;
    • Bobbili, Dheeraj R.;
    • Radivojkov‐Blagojevic, Milena;
    • Lichtner, Peter;
    • Singleton, Andrew B.;
    • Hernandez, Dena G.;
    • Edsall, Connor;
    • Gourraud, Pierre‐Antoine;
    • Mellick, George D.;
    • Zimprich, Alexander;
    • Pirker, Walter;
    • Rogaeva, Ekaterina;
    • Lang, Anthony E.;
    • Koks, Sulev
    Publication type:
    journal article

  • Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study.

    Published in:
    Movement Disorders, 2022, v. 37, n. 4, p. 857, doi. 10.1002/mds.28902
    By:
    • Domenighetti, Cloé;
    • Sugier, Pierre‐Emmanuel;
    • Ashok Kumar Sreelatha, Ashwin;
    • Schulte, Claudia;
    • Grover, Sandeep;
    • Mohamed, Océane;
    • Portugal, Berta;
    • May, Patrick;
    • Bobbili, Dheeraj R.;
    • Radivojkov‐Blagojevic, Milena;
    • Lichtner, Peter;
    • Singleton, Andrew B.;
    • Hernandez, Dena G.;
    • Edsall, Connor;
    • Mellick, George D.;
    • Zimprich, Alexander;
    • Pirker, Walter;
    • Rogaeva, Ekaterina;
    • Lang, Anthony E.;
    • Koks, Sulev
    Publication type:
    Article

  • Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource.

    Published in:
    Movement Disorders, 2021, v. 36, n. 8, p. 1795, doi. 10.1002/mds.28549
    By:
    • Iwaki, Hirotaka;
    • Leonard, Hampton L.;
    • Makarious, Mary B.;
    • Bookman, Matt;
    • Landin, Barry;
    • Vismer, David;
    • Casey, Bradford;
    • Gibbs, J. Raphael;
    • Hernandez, Dena G.;
    • Blauwendraat, Cornelis;
    • Vitale, Daniel;
    • Song, Yeajin;
    • Kumar, Dinesh;
    • Dalgard, Clifton L.;
    • Sadeghi, Mahdiar;
    • Dong, Xianjun;
    • Misquitta, Leonie;
    • Scholz, Sonja W.;
    • Scherzer, Clemens R.;
    • Nalls, Mike A.
    Publication type:
    Article

  • The Parkinson's Disease DNA Variant Browser.

    Published in:
    Movement Disorders, 2021, v. 36, n. 5, p. 1250, doi. 10.1002/mds.28488
    By:
    • Kim, Jonggeol J.;
    • Makarious, Mary B.;
    • Bandres‐Ciga, Sara;
    • Gibbs, Jesse Raphael;
    • Ding, Jinhui;
    • Hernandez, Dena G.;
    • Brooks, Janet;
    • Grenn, Francis P.;
    • Iwaki, Hirotaka;
    • Singleton, Andrew B.;
    • Nalls, Mike A.;
    • Blauwendraat, Cornelis
    Publication type:
    Article

  • Penetrance of Parkinson's Disease in LRRK2 p.G2019S Carriers Is Modified by a Polygenic Risk Score.

    Published in:
    2020
    By:
    • Iwaki, Hirotaka;
    • Blauwendraat, Cornelis;
    • Makarious, Mary B.;
    • Bandrés‐Ciga, Sara;
    • Leonard, Hampton L.;
    • Gibbs, J. Raphael;
    • Hernandez, Dena G.;
    • Scholz, Sonja W.;
    • Faghri, Faraz;
    • Nalls, Mike A.;
    • Singleton, Andrew B.;
    • Noyce, Alastair J;
    • Kaiyrzhanov, Rauan;
    • Middlehurst, Ben;
    • Kia, Demis A;
    • Tan, Manuela;
    • Houlden, Henry;
    • Morris, Huw R;
    • Plun‐Favreau, Helene;
    • Holmans, Peter
    Publication type:
    journal article

  • Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts.

    Published in:
    2019
    By:
    • Iwaki, Hirotaka;
    • Blauwendraat, Cornelis;
    • Leonard, Hampton L.;
    • Kim, Jonggeol J.;
    • Liu, Ganqiang;
    • Maple‐Grødem, Jodi;
    • Corvol, Jean‐Christophe;
    • Pihlstrøm, Lasse;
    • Nimwegen, Marlies;
    • Hutten, Samantha J.;
    • Nguyen, Khanh‐Dung H.;
    • Rick, Jacqueline;
    • Eberly, Shirley;
    • Faghri, Faraz;
    • Auinger, Peggy;
    • Scott, Kirsten M.;
    • Wijeyekoon, Ruwani;
    • Van Deerlin, Vivianna M.;
    • Hernandez, Dena G.;
    • Gibbs, J. Raphael
    Publication type:
    journal article

  • Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.

    Published in:
    2019
    By:
    • Blauwendraat, Cornelis;
    • Heilbron, Karl;
    • Vallerga, Costanza L.;
    • Bandres‐Ciga, Sara;
    • von Coelln, Rainer;
    • Pihlstrøm, Lasse;
    • Simón‐Sánchez, Javier;
    • Schulte, Claudia;
    • Sharma, Manu;
    • Krohn, Lynne;
    • Siitonen, Ari;
    • Iwaki, Hirotaka;
    • Leonard, Hampton;
    • Noyce, Alastair J.;
    • Tan, Manuela;
    • Gibbs, J. Raphael;
    • Hernandez, Dena G.;
    • Scholz, Sonja W.;
    • Jankovic, Joseph;
    • Shulman, Lisa M.
    Publication type:
    journal article

  • Another explanation for apparent epistasis.

    Published in:
    Nature, 2014, v. 514, n. 7520, p. E3, doi. 10.1038/nature13691
    By:
    • Wood, Andrew R.;
    • Tuke, Marcus A.;
    • Melzer, David;
    • Frayling, Timothy M.;
    • Weedon, Michael N.;
    • Nalls, Mike A.;
    • Singleton, Andrew B.;
    • Hernandez, Dena G.;
    • Bandinelli, Stefania;
    • Ferrucci, Luigi
    Publication type:
    Article

  • Identification of Nine Novel Loci Associated with White Blood Cell Subtypes in a Japanese Population.

    Published in:
    PLoS Genetics, 2011, v. 7, n. 6, p. 1, doi. 10.1371/journal.pgen.1002067
    By:
    • Okada, Yukinori;
    • Hirota, Tomomitsu;
    • Kamatani, Yoichiro;
    • Takahashi, Atsushi;
    • Ohmiya, Hiroko;
    • Kumasaka, Natsuhiko;
    • Higasa, Koichiro;
    • Yamaguchi-Kabata, Yumi;
    • Hosono, Naoya;
    • Nalls, Michael A.;
    • Ming Huei Chen;
    • van Rooij, Frank J. A.;
    • Smith, Albert V.;
    • Tanaka, Toshiko;
    • Couper, David J.;
    • Zakai, Neil A.;
    • Ferrucci, Luigi;
    • Longo, Dan L.;
    • Hernandez, Dena G.;
    • Witteman, Jacqueline C. M.
    Publication type:
    Article

  • Genome-Wide Meta-Analysis for Serum Calcium Identifies Significantly Associated SNPs near the Calcium-Sensing Receptor (CASR ) Gene.

    Published in:
    PLoS Genetics, 2010, v. 6, n. 7, p. 1, doi. 10.1371/journal.pgen.1001035
    By:
    • Kapur, Karen;
    • Johnson, Toby;
    • Beckmann, Noam D.;
    • Sehmi, Joban;
    • Tanaka, Toshiko;
    • Kutalik, Zoltán;
    • Styrkarsdottir, Unnur;
    • Weihua Zhang;
    • Marek, Diana;
    • Gudbjartsson, Daniel F.;
    • Milaneschi, Yuri;
    • Holm, Hilma;
    • DiIorio, Angelo;
    • Waterworth, Dawn;
    • Yun Li;
    • Singleton, Andrew B.;
    • Bjornsdottir, Unnur S.;
    • Sigurdsson, Gunnar;
    • Hernandez, Dena G.;
    • DeSilva, Ranil
    Publication type:
    Article

  • Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain.

    Published in:
    PLoS Genetics, 2010, v. 6, n. 5, p. 1, doi. 10.1371/journal.pgen.1000952
    By:
    • Gibbs, J. Raphael;
    • van der Brug, Marcel P.;
    • Hernandez, Dena G.;
    • Traynor, Bryan J.;
    • Nalls, Michael A.;
    • Shiao-Lin Lai;
    • Arepalli, Sampath;
    • Dillman, Allissa;
    • Rafferty, Ian P.;
    • Troncoso, Juan;
    • Johnson, Robert;
    • Zielke, H. Ronald;
    • Ferrucci, Luigi;
    • Longo, Dan L.;
    • Cookson, Mark R.;
    • Singleton, Andrew B.
    Publication type:
    Article