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- Title
Preoperative autologous blood donation reduces the need for allogeneic blood products: a prospective randomized study.
- Authors
Bouchard D; Marcheix B; Al-Shamary S; Eynden FV; Demers P; Robitaille D; Pellerin M; Perrault LP; Carrier M; Bouchard, Denis; Marcheix, Bertrand; Al-Shamary, Sfoug; Vanden Eynden, Frédéric; Demers, Philippe; Robitaille, Danielle; Pellerin, Michel; Perrault, Louis P; Carrier, Michel
- Abstract
<bold>Objective: </bold>We sought to assess the efficacy of preoperative autologous blood donation in reducing patient exposure to allogeneic blood products following elective cardiac surgery.<bold>Methods: </bold>We included 48 patients in a prospective study and randomly assigned them into the control or treatment group. We excluded patients with aortic stenosis, main trunk stenosis and unstable angina. Group A (n=23; coronary disease n=21 and valvular disease n=2) was the control group, and group B (n=25; coronary disease n=21, valvular disease n=4) received preoperative autologous blood donation. All patients had cardiopulmonary bypass surgery, and we processed mediastinal blood with a cell-saver device before reinfusion. All patients received aprotinin, and we reinfused blood shed from the mediastinum postoperatively.<bold>Results: </bold>No major peri- or postoperative complications occurred. We interrupted preoperative blood donation in 2 patients (8%) because of worsened angina pectoris. The mean time between the first blood donation and surgery was 22.5 (standard deviation [SD] 9.4, range 12-50) days. In group A, 9 patients (39.1%) were exposed to allogeneic blood products. In group B, 11 patients (47.8%) were exposed to blood products (p=0.73), and 4 (16%) were exposed to allogeneic blood products (p=0.036).<bold>Conclusion: </bold>Preoperative blood donation was completed in 92% of the targeted low-risk population. The procedure significantly reduced exposure to perioperative allogeneic blood products.
- Publication
Canadian Journal of Surgery, 2008, Vol 51, Issue 6, p422
- ISSN
0008-428X
- Publication type
journal article