We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Perivascular Adipose Tissue-Derived PDGF-D Contributes to Aortic Aneurysm Formation During Obesity.
- Authors
Ze-Bei Zhang; Cheng-Chao Ruan; Jing-Rong Lin; Lian Xu; Xiao-Hui Chen; Ya-Nan Du; Meng-Xia Fu; Ling-Ran Kong; Ding-Liang Zhu; Ping-Jin Gao; Zhang, Ze-Bei; Ruan, Cheng-Chao; Lin, Jing-Rong; Xu, Lian; Chen, Xiao-Hui; Du, Ya-Nan; Fu, Meng-Xia; Kong, Ling-Ran; Zhu, Ding-Liang; Gao, Ping-Jin
- Abstract
Obesity increases the risk of vascular diseases, including aortic aneurysm (AA). Perivascular adipose tissue (PVAT) surrounding arteries are altered during obesity. However, the underlying mechanism of adipose tissue, especially PVAT, in the pathogenesis of AA is still unclear. Here we showed that angiotensin II (AngII) infusion increases the incidence of AA in leptin-deficient obese mice (ob/ob) and high-fat diet-induced obese mice with adventitial inflammation. Furthermore, transcriptome analysis revealed that platelet-derived growth factor-D (PDGF-D) was highly expressed in the PVAT of ob/ob mice. Therefore, we hypothesized that PDGF-D mediates adventitial inflammation, which provides a direct link between PVAT dysfunction and AA formation in AngII-infused obese mice. We found that PDGF-D promotes the proliferation, migration, and inflammatory factors expression in cultured adventitial fibroblasts. In addition, the inhibition of PDGF-D function significantly reduced the incidence of AA in AngII-infused obese mice. More importantly, adipocyte-specific PDGF-D transgenic mice are more susceptible to AA formation after AngII infusion accompanied by exaggerated adventitial inflammatory and fibrotic responses. Collectively, our findings reveal a notable role of PDGF-D in the AA formation during obesity, and modulation of this cytokine might be an exploitable treatment strategy for the condition.
- Subjects
ADIPOSE tissues; AORTIC aneurysm treatment; ANGIOTENSIN II; PLATELET-derived growth factor; FIBROBLASTS
- Publication
Diabetes, 2018, Vol 67, Issue 8, p1549
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/db18-0098