We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Towards Understanding Neurodegenerative Diseases: Insights from Caenorhabditis elegans.
- Authors
Wu, Yingjie; Chen, Yining; Yu, Xiaochun; Zhang, Minxing; Li, Zhaoyu
- Abstract
The elevated occurrence of debilitating neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Alzheimer's disease (AD), Parkinson's disease (PD) and Machado–Joseph disease (MJD), demands urgent disease-modifying therapeutics. Owing to the evolutionarily conserved molecular signalling pathways with mammalian species and facile genetic manipulation, the nematode Caenorhabditis elegans (C. elegans) emerges as a powerful and manipulative model system for mechanistic insights into neurodegenerative diseases. Herein, we review several representative C. elegans models established for five common neurodegenerative diseases, which closely simulate disease phenotypes specifically in the gain-of-function aspect. We exemplify applications of high-throughput genetic and drug screenings to illustrate the potential of C. elegans to probe novel therapeutic targets. This review highlights the utility of C. elegans as a comprehensive and versatile platform for the dissection of neurodegenerative diseases at the molecular level.
- Subjects
CAENORHABDITIS elegans; NEURODEGENERATION; HUNTINGTON disease; AMYOTROPHIC lateral sclerosis; ALZHEIMER'S disease; PARKINSON'S disease
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 1, p443
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25010443