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- Title
Fluoroquinolone-Based Organic Salts (GUMBOS) with Antibacterial Potential.
- Authors
Costa, Fábio M. S.; Granja, Andreia; Pérez, Rocío L.; Warner, Isiah M.; Reis, Salette; Passos, Marieta L. C.; Saraiva, M. Lúcia M. F. S.
- Abstract
Antimicrobial resistance is a silent pandemic considered a public health concern worldwide. Strategic therapies are needed to replace antibacterials that are now ineffective. One approach entails the use of well-known antibacterials along with adjuvants that possess non-antibiotic properties but can extend the lifespan and enhance the effectiveness of the treatment, while also improving the suppression of resistance. In this regard, a group of uniform materials based on organic salts (GUMBOS) presents an alternative to this problem allowing the combination of antibacterials with adjuvants. Fluoroquinolones are a family of antibacterials used to treat respiratory and urinary tract infections with broad-spectrum activity. Ciprofloxacin and moxifloxacin-based GUMBOS were synthesized via anion exchange reactions with lithium and sodium salts. Structural characterization, thermal stability and octanol/water partition ratios were evaluated. The antibacterial profiles of most GUMBOS were comparable to their cationic counterparts when tested against Gram-positive S. aureus and Gram-negative E. coli, except for deoxycholate anion, which demonstrated the least effective antibacterial activity. Additionally, some GUMBOS were less cytotoxic to L929 fibroblast cells and non-hemolytic to red blood cells. Therefore, these agents exhibit promise as an alternative approach to combining drugs for treating infections caused by resistant bacteria.
- Subjects
ANTIBACTERIAL agents; ERYTHROCYTES; ESCHERICHIA coli; URINARY tract infections; RESPIRATORY infections; CIPROFLOXACIN; SODIUM salts; FLUOROQUINOLONES
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 21, p15714
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms242115714