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- Title
Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer.
- Authors
Coelho, Margarida; Capela, João; Anjo, Sandra I.; Pacheco, João; Fernandes, Margarida Sá; Amendoeira, Isabel; Jones, John G.; Raposo, Luís; Manadas, Bruno
- Abstract
Differentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and malignant thyroid cancer and the molecular alterations associated with malignancy to improve detection and signal potential diagnostic, prognostic, and therapeutic targets. Proteomics analysis of benign and malignant human thyroid tissue largely revealed changes indicating modifications in RNA regulation, a common cancer characteristic. In addition, changes in the immune system and cell membrane/endocytic processes were also suggested to be involved. Annexin A1 was considered a potential malignancy biomarker and, similarly to other annexins, it was found to increase in the malignant group. Furthermore, a bioinformatics approach points to the transcription factor Sp1 as being potentially involved in most of the alterations seen in the malignant thyroid nodules.
- Subjects
RNA regulation; THYROID cancer; TRANSCRIPTION factor Sp1; RNA modification &; restriction; SIGNAL detection; ANNEXINS
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 19, p14542
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms241914542