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- Title
PDE4 Inhibitors: Profiling Hits through the Multitude of Structural Classes.
- Authors
Jin, Jian; Mazzacuva, Francesca; Crocetti, Letizia; Giovannoni, Maria Paola; Cilibrizzi, Agostino
- Abstract
Cyclic nucleotide phosphodiesterases 4 (PDE4) are a family of enzymes which specifically promote the hydrolysis and degradation of cAMP. The inhibition of PDE4 enzymes has been widely investigated as a possible alternative strategy for the treatment of a variety of respiratory diseases, including chronic obstructive pulmonary disease and asthma, as well as psoriasis and other autoimmune disorders. In this context, the identification of new molecules as PDE4 inhibitors continues to be an active field of investigation within drug discovery. This review summarizes the medicinal chemistry journey in the design and development of effective PDE4 inhibitors, analyzed through chemical classes and taking into consideration structural aspects and binding properties, as well as inhibitory efficacy, PDE4 selectivity and the potential as therapeutic agents.
- Subjects
PHOSPHODIESTERASE inhibitors; CYCLIC nucleotide phosphodiesterases; DRUG discovery; CHRONIC obstructive pulmonary disease
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 14, p11518
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms241411518