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- Title
Time-Dependent Controlled Release of Ferulic Acid from Surface-Modified Hollow Nanoporous Silica Particles.
- Authors
Yamaguchi, Tetsuo; Kim, Taeho; Park, Jin-Kuen; Oh, Jae-Min
- Abstract
Release of ferulic acid from surface-functionalized hollow nanoporous silica particles (HNSPs) was investigated in deionized water (DI water) and in ethanol. The host material, an HNSP, was synthesized in the presence of polymer and surfactant templates, and the pore as well as the surface were modified with either pentyltriethoxysilane (PTS) or octyltriethoxysilane (OTS) through silane coupling reactions. The inner hollow space occupied a volume of ~45% of the whole HNSP with a 2.54 nm pore channel in the wall. The pore size was estimated to decrease to 1.5 nm and 0.5 nm via the PTS and OTS functionalization, respectively. The encapsulation efficiencies of the HNSP (25 wt%), PTS-functionalized HNSP (PTS-HNSP, 22 wt%) and OTS-functionalized HNSP (OST-HNSP, 25 wt%) toward ferulic acid were similar, while the %release in DI water and ethanol varied following HNSP > PTS-HNSP > OTS-HNSP. Release kinetic analyses with Korsmeyer–Peppas fitting suggested a trade-off relationship between the solvent's ability to access the HNSP and the affinity of ferulic acid to the surface, allowing us to understand the solvent's controlled release rate and mechanism.
- Subjects
FERULIC acid; SILICA; DEIONIZATION of water; MESOPOROUS silica; POLYMERS
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 13, p10560
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms241310560