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- Title
Special Issue "Precision Oncology in Melanoma Progression".
- Authors
D'Aguanno, Simona
- Abstract
Melanoma malignancy originates from pigment-producing melanocytes in the skin (cutaneous melanoma), in the choroid, ciliary body and iris of the eye (uveal melanoma) or in mucosal membranes from different sites (mucosal melanoma) [[1]]. Melanoma represents the most malignant type of skin cancer, with increasing incidence worldwide. As concerning somatic genetic alteration associated to melanoma, 40-50% of all melanoma patients harbor an activating BRAF mutation (mostly BRAF V600E), 20-30% NRAS mutations, 10-15% NF1 mutations and 1-3% KIT mutations [[2]]. Moreover, they demonstrated that CAF-secreted factors protect melanoma cells from acute toxicity of chemotherapy, while melanoma cells influence the paracrine activity of CAFs [[14]].
- Subjects
EXOSOMES; MELANOMA; ONCOLOGY; IMMUNE checkpoint inhibitors; PROGNOSIS
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 14, p7723
- ISSN
1661-6596
- Publication type
Editorial
- DOI
10.3390/ijms22147723