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- Title
TCR Transgenic Mice: A Valuable Tool for Studying Viral Immunopathogenesis Mechanisms.
- Authors
Cho, Yong-Bin; Lee, In-Gu; Joo, Yong-Hyun; Hong, So-Hee; Seo, Young-Jin
- Abstract
Viral infectious diseases are a significant burden on public health and the global economy, and new viral threats emerge continuously. Since CD4+ and CD8+ T cell responses are essential to eliminating viruses, it is important to understand the underlying mechanisms of anti-viral T cell-mediated immunopathogenesis during viral infections. Remarkable progress in transgenic (Tg) techniques has enabled scientists to more readily understand the mechanisms of viral pathogenesis. T cell receptor (TCR) Tg mice are extremely useful in studying T cell-mediated immune responses because the majority of T cells in these mice express specific TCRs for partner antigens. In this review, we discuss the important studies utilizing TCR Tg mice to unveil underlying mechanisms of T cell-mediated immunopathogenesis during viral infections.
- Subjects
TRANSGENIC mice; EMERGING infectious diseases; T cell receptors; VIRUS diseases; T cells; COMMUNICABLE diseases
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 24, p9690
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21249690