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- Title
Interactions between Host PPARs and Gut Microbiota in Health and Disease.
- Authors
Hasan, Arif Ul; Rahman, Asadur; Kobori, Hiroyuki
- Abstract
The human gastrointestinal tract is inhabited by many types of microbiota, including bacteria, viruses, and fungi. Dysregulations of their microenvironment are associated with various health problems, not only limited to gastrointestinal disorders, such as inflammatory bowel disease, but to impacts beyond the intestine. For example, intestinal microbiota can affect the liver in non-alcoholic fatty liver disease, visceral adipose tissue during adipogenesis, and the heart in atherosclerosis. The factors contributing to these pathogeneses involve the gut microbiota and the effector organs of the host, and everything in between. The nuclear receptor peroxisome proliferator-activated receptors (PPARs) are pivotal for the modulation of many of the pathogeneses mentioned above. It is, therefore, conceivable that, in the process of host-microbiota interactions, PPARs play important roles. In this review, we focus on the interactions between host PPARs in different organs and gut microbiota and their impacts on maintaining health and various diseases.
- Subjects
GASTROINTESTINAL system; INFLAMMATORY bowel diseases; ADIPOGENESIS; ATHEROSCLEROSIS; PEROXISOME proliferator-activated receptors
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 2, p387
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20020387