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- Title
Synthesis of Exocyclic Trisubstituted Alkenes via Nickel- Catalyzed Kumada-Type Cross-Coupling Reaction of gem- Difluoroalkenes with Di-Grignard Reagents.
- Authors
Dai, Wenpeng; Zhang, Xuxue; Zhang, Juan; Lin, Yingyin; Cao, Song
- Abstract
A practical, nickel-catalyzed Kumada-type double cross-coupling reaction of gem-difluoroalkenes with 1,4- or 1,5-di-Grignard reagents was developed. The reaction proceeded efficiently at room temperature and a variety of cyclization products, arylmethylenecyclopentanes and arylmethylenecyclohexanes, were obtained in high to excellent yields, respectively.
- Subjects
CHEMICAL synthesis; ALKENE derivatives; SUBSTITUTION reactions; NICKEL catalysts; COUPLING reactions (Chemistry); GRIGNARD reagents; RING formation (Chemistry)
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 2, p183
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201500889