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- Title
Optimized and combined T<sub>1</sub> and B<sub>1</sub> mapping technique for fast and accurate T<sub>1</sub> quantification in contrast-enhanced abdominal MRI.
- Authors
Treier, Reto; Steingoetter, Andreas; Fried, Michael; Schwizer, Werner; Boesiger, Peter
- Abstract
Fast T1 mapping techniques are a valuable means of quantitatively assessing the distribution and dynamics of intravenously or orally applied paramagnetic contrast agents (CAs) by noninvasive imaging. In this study a fast T1 mapping technique based on the variable flip angle (VFA) approach was optimized for accurate T1 quantification in abdominal contrast-enhanced (CE) MRI. Optimization methods were developed to maximize the signal-to-noise ratio (SNR) and ensure effective RF and gradient spoiling, as well as a steady state, for a defined T1 range of 100-800 ms and a limited acquisition time. We corrected B1 field inhomogeneities by performing an additional measurement using an optimized fast B1 mapping technique. High-precision in vitro and abdominal in vivo T1 maps were successfully generated at a voxel size of 2.8 × 2.8 × 15 mm3 and a temporal resolution of 2.3 s per T1 map on 1.5T and 3T MRI systems. The application of the proposed fast T1 mapping technique in abdominal CE-MRI enables noninvasive quantification of abdominal tissue perfusion and vascular permeability, and offers the possibility of quantitatively assessing dilution, distribution, and mixing processes of labeled solutions or drugs in the gastrointestinal tract. Magn Reson Med 57:568-576, 2007. © 2007 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2007, Vol 57, Issue 3, p568
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.21177