We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Efficacy of cyanoacrylate in the prevention of delayed bleeding after endoscopic mucosal resection of large colorectal polyps: a pilot study.
- Authors
Martines, Gennaro; Picciariello, Arcangelo; Dibra, Rigers; Trigiante, Giuseppe; Jambrenghi, O. Caputi; Chetta, Nicola; Altomare, Donato Francesco
- Abstract
Background: Postoperative bleeding is a common complication after endoscopic polypectomy, particularly after endoscopic mucosal resection (EMR) of large non-pedunculated polyps, despite prophylactic clipping can reduce its occurrence. Cyanoacrylate glue has recently been proposed as a useful tool in reducing bleeding in surgery because of its adhesive and haemostatic properties. The aim of this study is to evaluate the usefulness of endoscopic application of a modified cyanoacrylate glue in the prevention of early or delayed post EMR bleeding. Methods: This is a pilot study. Inclusion criteria were patients between 18 and 75 years old affected by sessile or flat colonic polyps larger than 2 cm. Patients enrolled in the study were randomized in two groups: group A (EMR) and group B (EMR with the application of 0.3 ml of N-butyl-2-cyanoacrylate + methacryloxysulfolane—Glubran 2®). Results: Fifteen patients in both group A and B were enrolled. There were no intraoperative complications but haemostatic clipping was necessary in 3 patients in each group because of active bleeding. Delayed (after 24 h) bleeding occurred in two patients (13.3%) in group A requiring hospital readmission and re-do endoscopy with apposition of haemostatic clips. No case of bleeding was recorded in group B (p = 0.48). Conclusion: The results of this pilot study suggest a potential role of local spray application of Glubran®2 in reducing post-procedural bleeding.
- Subjects
ENDOSCOPIC surgery; POLYPECTOMY; COLON polyps; HEMORRHAGE; PILOT projects; SURGICAL complications
- Publication
International Journal of Colorectal Disease, 2020, Vol 35, Issue 11, p2141
- ISSN
0179-1958
- Publication type
Article
- DOI
10.1007/s00384-020-03678-9