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- Title
Prognostic factors in node-negative colorectal cancer: a retrospective study from a prospective database.
- Authors
Desolneux, Gregoire; Burtin, Pascal; Lermite, Emilie; Bergamaschi, Roberto; Hamy, Antoine; Arnaud, Jean
- Abstract
There is a need to identify a subgroup of high-risk patients with node-negative colorectal cancer who have a poor long-term prognosis and may benefit from adjuvant therapies. The aim of this study was to evaluate the prognostic impact of clinical and pathological parameters in a retrospective study from a prospective, continuous database of homogenously treated patients. This study included 362 patients operated in a single institution for Dukes A and B (node-negative) colorectal cancer. The median follow-up was 140 months. The prognostic value of 13 clinical and pathological parameters was investigated. Multivariate analysis identified six independent prognostic factors: age at time of diagnosis (hazard ratio (HR) = 1.076), number of lymph nodes removed (HR = 0.948), perineural invasion (HR = 2.173), venous invasion (HR = 1.959), lymphatic vessel invasion (HR = 2.126), and T4 stage (HR = 5.876). These parameters could be useful in identifying patients with high-risk node-negative colorectal cancer who should be presented to adjuvant therapy.
- Subjects
COLON cancer; RETROSPECTIVE studies; PROGNOSIS; ADJUVANT treatment of cancer; MULTIVARIATE analysis; LYMPH nodes
- Publication
International Journal of Colorectal Disease, 2010, Vol 25, Issue 7, p829
- ISSN
0179-1958
- Publication type
Article
- DOI
10.1007/s00384-010-0934-5