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- Title
Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation.
- Authors
Castel, David; Kergrohen, Thomas; Tauziède-Espariat, Arnault; Mackay, Alan; Ghermaoui, Samia; Lechapt, Emmanuèle; Pfister, Stefan M.; Kramm, Christof M.; Boddaert, Nathalie; Blauwblomme, Thomas; Puget, Stéphanie; Beccaria, Kévin; Jones, Chris; Jones, David T. W.; Varlet, Pascale; Grill, Jacques; Debily, Marie-Anne
- Abstract
2 Molecular and clinical portrait of H3 wild-type DMG patients. a Clinicopathological and molecular annotations are provided as bars for 19 histone H3 wild-type DMG patients. Samples are arranged in columns with genes labeled along rows. b Distribution of normalized EZHIP gene expression level, in H3-K27M (green, n = 20) and H3 wild-type (grey, n = 11) DMG patients. We propose that these EZHIP/H3-WT tumors need to be considered similar to canonical DIPG/DMG, thus extending the spectrum of DMG with PRC2 inhibition beyond H3-K27M mutation.
- Subjects
GLIOMAS; CENTRAL nervous system tumors
- Publication
Acta Neuropathologica, 2020, Vol 139, Issue 6, p1109
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-020-02142-w