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- Title
In vitro Antibacterial Activity of Chinfloxacin, a New Fluoroquinolone Antibiotic.
- Authors
Li, Guo-Qing; Yuan, Min; Yang, Xin-Yi; Li, Cong-Ran; Hu, Xin-Xin; Zhang, Wei-Xin; Lou, Ren-Hui; Guo, Hui-Yuan; You, Xuan-Wang; Cen, Shan; Jiang, Jian-Dong; You, Xue-Fu
- Abstract
Background: Chinfloxacin is a novel synthetic fluoroquinolone with a structure similar to moxifloxacin. The in vitro activity of chinfloxacin was evaluated in the current study. Method: Chinfloxacin was tested against a total of 1,739 clinical isolates representing 23 species using the agar dilution method. Studies of bactericidal activity, including minimum bactericidal concentrations (MBC) and time-kill curve determinations, were conducted according to the recommendations of the Clinical and Laboratory Standards Institute. Results: Minimum inhibitory concentrations (MIC)50s and MIC90s of chinfloxacin were found to be the same or 2-fold lower than those of moxifloxacin against gram-positive isolates except for Streptococcus pyogenes (against which chinfloxacin showed similar MIC50 as moxifloxacin but 2-fold higher MIC90), and the same as or 2-fold higher than those of moxifloxacin against gram-negative isolates. Chinfloxacin showed potent bactericidal activity with MBC/MIC ratios in the range of 1-2 for almost all the isolates tested. Time-kill curves further demonstrated chinfloxacin as a concentration-dependent bactericidal agent usually effective at concentrations of 2 MIC or higher. Conclusion: Chinfloxacin showed similar in vitro activity as moxifloxacin. Copyright © 2012 S. Karger AG, Basel
- Subjects
ANTIBACTERIAL agents; FLUOROQUINOLONES; MOXIFLOXACIN; STREPTOCOCCUS pyogenes; GRAM-positive bacterial infections; DILUTION; BACTERIAL disease treatment
- Publication
Chemotherapy (0009-3157), 2012, Vol 58, Issue 3, p175
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000337084