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- Title
Translational medicine: To the rescue of the failing heart.
- Authors
Bers, Donald M.; Harris, Samantha P.
- Abstract
The article describes a small-molecule drug omecamtiv mecarbil which enhances the activity of the motor protein myosin which is the force-generating protein of the heart. Omecamtiv mecarbil which is also an inotropic drug increases heartbeat strength by enhancing the ability of the myosin molecule to generate force. Moreover, agents such as omecamtiv mecarbil could contribute to future therapy for those who have heart failure.
- Subjects
MYOSIN; CARDIOTONIC agents; HEART beat; HEART failure treatment; TRANSLATIONAL research
- Publication
Nature, 2011, Vol 473, Issue 7345, p36
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/473036a