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- Title
Sensitivity of fluorophore-quencher labeled microbubbles to externally applied static pressure.
- Authors
Baohong Yuan
- Abstract
A fluorophore-quencher (F-Q) labeled microbubble system is proposed as a sensor for measuring externally applied static pressure distribution in a tumor. To quantify the sensitivity of such an F-Q bubble system to the externally applied pressure, a model describing bubble response to the static pressure was derived. Additionally, a model connecting the fluorescence lifetime and bubble radius was developed for the basic F-Q bubble system. The sensitivity is quantified based on these models given typical parameters. Results show that it is possible to resolve as low as 1 mm Hg pressure variation when both the F-Q bubble system and the measurement system are optimized. Strategies for optimizing an F-Q bubble system are discussed.
- Subjects
TUMORS; MICROBUBBLES; DIAGNOSTIC imaging; MEDICAL physics; MEDICAL technology
- Publication
Medical Physics, 2009, Vol 36, Issue 8, p3455
- ISSN
0094-2405
- Publication type
Article
- DOI
10.1118/1.3158734