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- Title
VSDI: a new era in functional imaging of cortical dynamics.
- Authors
Grinvald, Amiram; Hildesheim, Rina
- Abstract
During the last few decades, neuroscientists have benefited from the emergence of many powerful functional imaging techniques that cover broad spatial and temporal scales. We can now image single molecules controlling cell differentiation, growth and death; single cells and their neurites processing electrical inputs and sending outputs; neuronal circuits performing neural computations in vitro; and the intact brain. At present, imaging based on voltage-sensitive dyes (VSDI) offers the highest spatial and temporal resolution for imaging neocortical functions in the living brain, and has paved the way for a new era in the functional imaging of cortical dynamics. It has facilitated the exploration of fundamental mechanisms that underlie neocortical development, function and plasticity at the fundmental level of the cortical column.
- Subjects
IMAGING systems; SPECTROSCOPIC imaging; CELL differentiation; CELL death; NEUROPLASTICITY; NEOCORTEX
- Publication
Nature Reviews Neuroscience, 2004, Vol 5, Issue 11, p874
- ISSN
1471-003X
- Publication type
Article
- DOI
10.1038/nrn1536