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- Title
Cost-of-illness trajectories among people with multiple sclerosis by comorbidity: A register-based prospective study in Sweden.
- Authors
Bütepage, Greta; Esawi, Ahmed; Alexanderson, Kristina; Friberg, Emilie; Murley, Chantelle; Hillert, Jan; Karampampa, Korinna
- Abstract
Background: Comorbidities are common among people with multiple sclerosis (PwMS); yet, their impact on the cost-of-illness (COI) in MS is unknown. Objective: Explore the heterogeneity in COI trajectories among newly diagnosed PwMS in relation to type of comorbidity. Methods: A nationwide longitudinal cohort study, using prospectively collected Swedish register data for seven years. The COI/year of 639 PwMS diagnosed in 2006, when aged 25–60, was estimated until 2013. Using healthcare data, PwMS were categorised into six comorbidity groups: ocular; cardiovascular, genitourinary or cancer disease; musculoskeletal; mental; neurological other than MS; and injuries. One group of PwMS without comorbidity was also created. Group-based trajectory modelling was applied, examining different COI trajectories within each comorbidity group. Results: Across the seven follow-up years, PwMS with mental comorbidities had the highest COI overall (€36,482). Four COI trajectories were identified within each comorbidity group; the largest trajectory had high healthcare costs and productivity losses (36.3%–59.6% of PwMS, across all comorbidity groups). 59.6% of PwMS with mental comorbidity had high healthcare costs and productivity losses. Conclusion: High COI and heterogeneity in COI trajectories could be partly explained by the presence of chronic comorbidities in the year around MS diagnosis, including the presence of mental comorbidity.
- Subjects
SWEDEN; MULTIPLE sclerosis; COMORBIDITY; MEDICAL care costs; LONGITUDINAL method; GENITOURINARY diseases
- Publication
Multiple Sclerosis Journal - Experimental, Translational & Clinical, 2020, p1
- ISSN
2055-2173
- Publication type
Article
- DOI
10.1177/2055217320968597