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- Title
Impact of surgical staging for aggressive histology rectal cancers: a retrospective review.
- Authors
Kazi, Mufaddal; Nekkanti, Sri Siddhartha; Rohila, Jitender; Patel, Swapnil; Sukumar, Vivek; Desouza, Ashwin; Saklani, Avanish
- Abstract
Background: Poorly differentiated adenocarcinomas and signet ring adenocarcinomas are aggressive histological subtypes of rectal cancer with a high incidence of occult peritoneal metastasis. Methods: This was a retrospective review of aggressive histology of rectal cancer patients who underwent pre‐treatment surgical staging as part of ovarian transposition or ostomy creation for diversion at a single tertiary cancer centre between January 2014 and December 2019. Results: A total of 117 patients underwent surgical staging and were deemed non‐metastatic on imaging. Surgical staging led to the detection of metastasis in 29.9% of patients. This led to modification in treatment protocol in 20.5% and change in intent of therapy in 15.4%. The majority (80%) was found to have peritoneal disease with peritoneal carcinomatosis index <17. Only T4 disease predicted the presence of metastasis on surgical staging with an odds ratio of 2.69 (P = 0.035). Conclusions: A significant proportion of patients with aggressive histology rectal cancers are upstaged after surgical staging. Further investigation of this tool for staging is warranted.
- Subjects
RECTAL cancer; PERITONEAL cancer; HISTOLOGY; OSTOMY; CANCER patients; METASTASIS
- Publication
ANZ Journal of Surgery, 2021, Vol 91, Issue 3, pE119
- ISSN
1445-1433
- Publication type
Article
- DOI
10.1111/ans.16496