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- Title
COVID-19: How Effective Are the Repurposed Drugs and Novel Agents in Treating the Infection?
- Authors
Suet-May, Chow; Sin-Yee, Kuok; Jia-Qing, Lee; Pey-Wen, Goh; A/P Ranjit Singh, Harleen Kaur; Zhi-Zheng, Timothy Tan; Foo, Jhi-Biau; Hamzah, Sharina; Sellappans, Renukha; Hui-Yin, Yow
- Abstract
Coronavirus disease 2019 (COVID-19) induced by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has impacted the lives and wellbeing of many people. This globally widespread disease poses a significant public health concern that urges to discover an effective treatment. This review paper discusses the effectiveness of repurposed drugs used to treat COVID-19 and potential novel therapies for COVID-19. Among the various repurposed drugs, remdesivir is the only agent approved by the Food and Drug Administration (FDA) to treat COVID-19. On the other hand, several drugs have been listed in the Emergency Use Authorization (EUA) by the FDA to treat COVID-19, including casirivimab and imdevimab, baricitinib (in combination with remdesivir), bamlanivimab, tocilizumab, and IL-6 inhibitors. In addition, in vitro and clinical studies have suggested cepharanthine, sotrovimab, and XAV-19 as potential treatments to manage COVID-19. Due to inadequate understanding of COVID-19 and the rapid mutation of SARS-CoV-2, COVID-19 remains a threat to global public health, with vaccination considered the most effective method to decrease COVID-19 transmission currently. Nevertheless, with the intense efforts of clinical researchers globally, more promising treatments for COVID-19 will be established in the future.
- Subjects
UNITED States. Food &; Drug Administration; SARS-CoV-2; COVID-19; DRUG efficacy
- Publication
Sudan Journal of Medical Sciences, 2022, Vol 17, Issue 4, p498
- ISSN
1858-5051
- Publication type
Article
- DOI
10.18502/sjms.v17i4.12550