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- Title
Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-, Cefiderocol-Resistant ST-512 Klebsiella pneumoniae–Producing KPC-31, a D179Y Variant of KPC-3.
- Authors
Tiseo, Giusy; Falcone, Marco; Leonildi, Alessandro; Giordano, Cesira; Barnini, Simona; Arcari, Gabriele; Carattoli, Alessandra; Menichetti, Francesco
- Abstract
A 68-year-old man had recurrent bacteremia by Klebsiella pneumoniae carbapenemase (KPC)–producing K. pneumoniae resistant to ceftazidime-avibactam and cefiderocol. The sequencing of a target region showed that it harbored a KPC-3 variant enzyme (D179Y; KPC-31), which confers resistance to ceftazidime-avibactam and restores meropenem susceptibility. The patient was successfully treated with meropenem-vaborbactam.
- Subjects
SALVAGE therapy; KLEBSIELLA pneumoniae; KLEBSIELLA; TREATMENT effectiveness; CARBAPENEMASE
- Publication
Open Forum Infectious Diseases, 2021, Vol 8, Issue 6, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofab141