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- Title
Immunoexpression of Macroh2a in Uveal Melanoma.
- Authors
Salvatorelli, Lucia; Puzzo, Lidia; Bartoloni, Giovanni; Palmucci, Stefano; Longo, Antonio; Russo, Andrea; Reibaldi, Michele; Vinciguerra, Manlio; Li Volti, Giovanni; Caltabiano, Rosario
- Abstract
MacroH2A is a histone variant whose expression has been studied in several neoplasms, including cutaneous melanomas (CMs). In the literature, it has been demonstrated that macroH2A.1 levels gradually decrease during CM progression, and a high expression of macroH2A.1 in CM cells relates to a better prognosis. Although both uveal and cutaneous melanomas arise from melanocytes, uveal melanoma (UM) is biologically and genetically distinct from the more common cutaneous melanoma. Metastasis to the liver is a frequent occurrence in UM, and about 40%–50% of patients die of metastatic disease, even with early diagnosis, proper treatment, and close follow-up. We wanted to investigate macroH2A.1 immunohistochemical expression in UM. Our results demonstrated that mH2A.1 expression was higher in metastatic UM (21/23, 91.4%), while only 18/32 (56.3%). UMs without metastases showed mH2A.1 staining. These data could suggest a possible prognostic role for mH2A.1 and could form a basis for developing new pharmacological strategies for UM treatment.
- Subjects
MELANOMA; UVEA; LIVER metastasis; EARLY diagnosis
- Publication
Applied Sciences (2076-3417), 2019, Vol 9, Issue 16, p3244
- ISSN
2076-3417
- Publication type
Article
- DOI
10.3390/app9163244