We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Is the short insulin tolerance test safe and reproducible?
- Authors
Chen, C.-C.; Wang, T.-Y.; Hsu, S.-Y.; Chen, R.-H.; Chang, C.-T.; Chen, S.-J.
- Abstract
The short insulin tolerance test (SITT) is described as a simple method to measure insulin sensitivity. To investigate the safety and reproducibility of the SITT, 16 healthy volunteers underwent two SITTs within 1 week. Intravenous insulin (0.05 U kg−1 body weight) was injected into an antecubital vein. Blood samples were collected from the contralateral antecubital vein. The insulin-induced glucose disposal rate ( Kitt) was calculated from the slope of the regression line of the logarithm of blood glucose against time during the first 3-15 min. Plasma glucose concentrations fell below 2.8 mmol l−1 in 4 of the 32 tests and below 2.2 mmol l−1 in 1 of these 4. Five subjects had mild hypoglycaemic symptoms, three of whom had plasma glucose concentrations below 2.8 mmol l−1 in at least one SITT. The mean Kitt was 4.2 % min−1 (range 0.8-8.4) for the first test and 3.4 % min−1 (range 0.1-6.8) for the second test. The mean within-subject coefficient of variation was 30.7 %. We conclude that SITT should be applied with caution especially on insulin sensitive subjects and has poor reproducibility using 0.05 U kg−1 body weight of insulin injection, venous sampling, uncontrolled physical activity and uncontrolled dietary composition. Whether 0.1 U kg−1 body weight of insulin injection and arterialized venous blood sampling as in the original description of this test can improve the reproducibility of the SITT needs further investigation. © 1998 John Wiley & Sons, Ltd.
- Publication
Diabetic Medicine, 1998, Vol 15, Issue 11, p924
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1002/(SICI)1096-9136(1998110)15:11<924::AID-DIA699>3.0.CO;2-H