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- Title
Diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the Multiethnic Cohort Study (MEC).
- Authors
Aumueller, Nicole; Boushey, Carol J.; Franke, Adrian A.; Cooney, Robert V.; Monroe, Kristine R.; Haiman, Christopher A.; Wilkens, Lynne R.; Kolonel, Laurence N.; Le Marchand, Loic; Maskarinec, Gertraud
- Abstract
<bold>Background/objectives: </bold>This study examined the long-term relation of lipid-soluble micronutrients with diet quality as assessed by four a priori-defined dietary patterns.<bold>Subjects/methods: </bold>In a prospective design, nutritional biomarkers (carotenoids, tocopherols, retinol, and coenzyme Q10) were measured using a validated HPLC-based assay. General linear models were applied to obtain covariate-adjusted means of biomarkers for tertiles of four a priori diet quality indices: Healthy Eating Index (HEI) 2010, Alternative HEI (AHEI) 2010, Alternate Mediterranean Diet Score (aMED), and Dietary Approaches to Stop Hypertension (DASH). For a subcohort of 8367 participants within the Multiethnic Cohort (MEC), diet was assessed by a validated quantitative food frequency questionnaire in 1993-96 and serum was collected in 2001-06.<bold>Results: </bold>Participants with the highest diet-quality scores had significantly higher serum concentrations of all carotenoids, total tocopherols, and α-tocopherol, whereas γ-tocopherol was inversely associated with diet quality. Adjusted means for the lowest vs. highest tertile of HEI 2010 were 1.2 vs. 1.5 mg/L for total carotenoids, 11.4 vs. 12.3 mg/L for total tocopherols, and 1.9 vs. 1.6 mg/L for γ-tocopherol (ptrend < 0.0001). The associations for the other dietary indices were similar; no indication for sex and ethnic differences was detected. Vegetable and fruit components were major predictors of most circulating micronutrients, but most other components were also associated.<bold>Conclusions: </bold>Higher diet-quality scores measured by four a priori diet quality indices were significantly associated higher serum concentrations of carotenoids and α-tocopherol, whereas γ-tocopherol was inversely associated with diet quality.
- Subjects
CALIFORNIA; HAWAII; RESEARCH; NUTRITIONAL assessment; PREDICTIVE tests; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; QUESTIONNAIRES; RESEARCH funding; MICRONUTRIENTS; ETHNIC groups; LIPIDS; LONGITUDINAL method
- Publication
European Journal of Clinical Nutrition, 2019, Vol 73, Issue 5, p703
- ISSN
0954-3007
- Publication type
journal article
- DOI
10.1038/s41430-018-0272-1