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- Title
Assessment of serum interleukin 6 in a sample of Egyptian patients with schizophrenia.
- Authors
Ella, Eman Ibrahim Abo El; Rabie, Eman S.; Sheikh, Mona Mahmoud El; Ghamry, Reem Hassan El; Hotar, Mostafa Salah; Gabrielle, Fiby Fayez
- Abstract
Background: Inflammation has been demonstrated to play a pathophysiological function in schizophrenia. Raised interleukin-6 (IL-6) levels have been the most consistently linked to schizophrenia. It was hypothesized that IL-6 contributed to the development of both adverse and beneficial symptoms. The aim of the study was to estimate the level of serum IL-6 in patients with schizophrenia and its relation to positive in addition to negative symptoms. Patient and methods: This case–control descriptive cross-sectional study was conducted on 40 patients, divided into two groups: 20 individuals in Group A (patients group) were treatment-naive for their first episode of schizophrenia, and 20 volunteers in Group B (control group) were matched for gender and age to the patient group. Both groups were evaluated for their serum interleukin-6 levels using the ELISA method. Patients and controls were recruited from the Okasha Institute of Psychiatry, Faculty of Medicine, and Ain Shams University Hospitals. Results: Cases with schizophrenia who were experiencing their first episode and had not yet begun any form of therapy had a considerably higher mean serum IL-6 level compared to the healthy control group. Conclusion: The level of serum interleukin 6 in first-episode treatment-naïve individuals with schizophrenia is higher than that of healthy controls, revealing a probable underlying immunological pathology. However, serum interleukin-6 levels were not significantly correlated with positive, negative, or general psychopathology symptoms.
- Subjects
EGYPTIANS; PEOPLE with schizophrenia; INTERLEUKIN-6; PATHOLOGICAL psychology; CASE-control method
- Publication
Middle East Current Psychiatry, 2024, Vol 31, Issue 1, p1
- ISSN
2090-5408
- Publication type
Article
- DOI
10.1186/s43045-024-00409-6