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- Title
Cyclin E in normal and neoplastic cell cycles.
- Authors
Hwang, Harry C; Clurman, Bruce E
- Abstract
Cyclin E-Cdk2 has long been considered an essential and master regulator of progression through G1?phase of the cell cycle. Although recent mouse models have prompted a rethinking of cyclin E function in mammals, it remains clear that cyclin E impacts upon many processes central to cell division. Normal cells maintain strict control of cyclin E activity, and this is commonly disrupted in cancer cells. Moreover, cyclin E deregulation is thought to play a fundamental role in tumorigenesis. In this review, we discuss the regulation and functions of cyclin E in normal and neoplastic mammalian cells.Oncogene (2005) 24, 2776-2786. doi:10.1038/sj.onc.1208613
- Subjects
TUMORS; CELL cycle; MICE; MODELS &; modelmaking; MAMMALS; CELLS
- Publication
Oncogene, 2005, Vol 24, Issue 17, p2776
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1208613