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- Title
LDL Cholesterol Goals in High-Risk Patients: How Low Do We Go and How Do We Get There?
- Authors
Besseling, Joost; Capelleveen, Julian; Kastelein, John; Hovingh, G.
- Abstract
It is widely recognised that low-density lipoprotein cholesterol (LDL-C) is one of the most important and modifiable risk factors for cardiovascular disease (CVD). Statins (HMG-CoA reductase inhibitors) have consistently been shown to decrease both LDL-C and CVD risk in almost all patient categories, with the exception of heart and kidney failure as well as advanced aortic stenosis. As a consequence, statins have become the cornerstone in current prevention guidelines. In patients who do not reach the LDL-C target, combination therapy with additional LDL-C lowering drugs (e.g. ezetimibe, bile acid sequestrants or fibrates) should be considered. Guidelines provide different LDL-C levels to strive for, depending on the CVD risk. In this review, we describe the rationale for these LDL-C targets and how these goals might be reached by current and future therapies.
- Subjects
CARDIOVASCULAR disease prevention; CLOFIBRIC acid; COMBINATION drug therapy; GOAL (Psychology); LOW density lipoproteins; MEDICAL protocols; RISK assessment; STATINS (Cardiovascular agents); THERAPEUTICS
- Publication
Drugs, 2013, Vol 73, Issue 4, p293
- ISSN
0012-6667
- Publication type
Journal Article
- DOI
10.1007/s40265-013-0028-0