We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Incremental significance of myocardial oedema for prognosis in hypertrophic cardiomyopathy.
- Authors
Xu, Ziqian; Wang, Jie; Cheng, Wei; Wan, Ke; Li, Weihao; Pu, Lutong; Xu, Yuanwei; Sun, Jiayu; Han, Yuchi; Chen, Yucheng
- Abstract
Aims To explore the prognosis of myocardial oedema measured by T2 mapping in hypertrophic cardiomyopathy (HCM). Methods and results A total of 674 patients with HCM (age: 50 ± 15 years, 60.5% males) who underwent cardiovascular magnetic resonance were prospectively enrolled from 2011 to 2020. One hundred healthy controls (age: 48 ± 19 years, 58.0% males) were included for comparison. Myocardial oedema was quantitatively measured by T2 mapping in both global and segmental myocardium. The endpoints were defined as a combination of cardiovascular death and appropriate implantable cardioverter defibrillator discharge. During a median follow-up of 36 months (interquartile range: 24–60 months), 55 patients (8.2%) had cardiovascular events. Patients with cardiovascular events had a higher T2 max, T2 min, and T2 global values (all P < 0.001) than patients who remained event free. Survival analysis demonstrated that patients with HCM with late gadolinium enhancement [LGE(+)] and T2 max ≥44.9 ms had a higher risk of developing cardiovascular events (P < 0.001). A multivariate Cox regression analysis showed that T2 max, T2 min, and T2 global provided significant prognostic value to predict cardiovascular events (all P < 0.001). According to the C-index (0.825, 0.814), net reclassification index (0.612, 0.536, both P < 0.001), and integrative discrimination index (0.029, 0.029, both P < 0.05), T2 max or T2 min significantly increased the predictive performance of established risk factors, including extensive LGE. Conclusion Patients with HCM with LGE(+) and higher T2 had worse prognosis than those with LGE(+) and lower T2.
- Subjects
CARDIOVASCULAR disease related mortality; CARDIOMYOPATHIES; CARDIAC hypertrophy; MULTIVARIATE analysis; MAGNETIC resonance imaging; QUANTITATIVE research; COMPARATIVE studies; DESCRIPTIVE statistics; SURVIVAL analysis (Biometry); RESEARCH funding; COMPUTER-assisted image analysis (Medicine); EDEMA; PROPORTIONAL hazards models
- Publication
European Heart Journal - Cardiovascular Imaging, 2023, Vol 24, Issue 7, p876
- ISSN
2047-2404
- Publication type
Article
- DOI
10.1093/ehjci/jead065