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- Title
Engineered Organosilica Hybrid Micelles for Photothermal‐enhanced Starvation Cancer Therapy.
- Authors
Li, Xianglong; Wu, Huan; Jiang, Cong; Zou, Jinglin; Wang, Qinghua; Guan, Mengjia; Hao, Ji‐Na; Cao, Yuanyuan; Li, Yongsheng
- Abstract
Glucose oxidase (GOD)‐based starvation therapy (ST), which inhibits the growth and proliferation of cancer cells by consuming glucose, has attracted intensive attention as an emerging non‐invasive method for fighting cancers. However, the enzyme activity of GOD is greatly limited in vivo because of its optimal catalytic activity in the temperature range of 43–60 °C. Herein, a photothermal‐enhanced starvation strategy is developed based on our engineered organosilica hybrid micelles (TiO2‐x@POMs‐GOD), in which the fluoride‐doped TiO2‐x with photothermal properties is encapsulated in the cores of organosilica cross‐linked micelles and GOD is immobilized on the carboxyl groups of PAA segments. With its internalization by cancer cells, the conjugated GOD can effectively deplete glucose to achieve the ST effect, which can be remarkably enhanced by the loaded fluoride‐doped TiO2‐x with NIR laser irradiation, thus cooperatively contributing to the efficient treatment of TiO2‐x@POMs‐GOD on various cancer cells. This suggests great potential for TiO2‐x@POMs‐GOD in photothermal‐enhanced ST in vivo.
- Subjects
MICELLES; GLUCOSE oxidase; STARVATION; CANCER treatment; CANCER cell growth; POLYVINYLIDENE fluoride
- Publication
Chemistry - An Asian Journal, 2022, Vol 17, Issue 17, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202200570