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- Title
Genetics and Epigenetics in Allergic Rhinitis.
- Authors
Choi, Bo Yoon; Han, Munsoo; Kwak, Ji Won; Kim, Tae Hoon
- Abstract
The pathogenesis of allergic rhinitis is associated with genetic, environmental, and epigenetic factors. Genotyping of single nucleotide polymorphisms (SNPs) is an advanced technique in the field of molecular genetics that is closely correlated with genome-wide association studies (GWASs) in large population groups with allergic diseases. Many recent studies have paid attention to the role of epigenetics, including alteration of DNA methylation, histone acetylation, and miRNA levels in the pathogenesis of allergic rhinitis. In this review article, genetics and epigenetics of allergic rhinitis, including information regarding functions and significance of previously known and newly-discovered genes, are summarized. Directions for future genetic and epigenetic studies of allergic rhinitis are also proposed.
- Subjects
ALLERGIC rhinitis; EPIGENETICS; GENETICS; MOLECULAR genetics; SINGLE nucleotide polymorphisms; GENOME-wide association studies; HISTONE methylation
- Publication
Genes, 2021, Vol 12, Issue 12, p2004
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes12122004