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- Title
Refining evidence-based retinopathy of prematurity screening guidelines: The SCREENROP study.
- Authors
Sabri, Kourosh; Shivananda, Sandesh; Farrokhyar, Forough; Selvitella, Alessandro; Kin, Bethany Easterbrook B; Seidlitz, Wendy; Lee, Shoo K; Strabismus, Canadian Neonatal Network and the Canadian Association of Pediatric Ophthalmology and
- Abstract
Purpose Retinopathy of prematurity (ROP) is a potentially blinding condition affecting premature infants for which less than 10% of babies undergoing screening require treatment. This study assessed and validated predictors of developing clinically significant ROP (type 2 or worse) and ROP requiring treatment. Design Nationwide retrospective cohort study. Methods This study included infants born between January 2014 and June 2016, admitted to level 3 neonatal intensive care units across Canada who underwent ROP screening. Data were derived from the Canadian Neonatal Network database. Predefined ≥ 1% risk for clinically significant retinopathy or prematurity and ROP requiring treatment was set as threshold for screening. Thirty-two potential predictors were analyzed, to identify and validate the most important ones for predicting clinically significant ROP. The predictors were determined on a derivation cohort and tested on a validation cohort. Multivariable logistic regression modeling was used for analysis. Results Using a sample of 4,888 babies and analyzing 32 potential predictors, capturing babies with ≥1% risk of developing clinically significant ROP equated to screening babies with birth weight (BW) <1,300 g or gestational age (GA) <30 weeks while capturing babies with ≥1% risk of requiring ROP treatment equated to screening babies with BW <1,200 g or GA <29 weeks. Conclusions The Canadian ROP screening criteria can be modified to screen babies with BW <1,200 g or GA <30 weeks. Using these criteria, babies requiring treatment would be identified while reducing the number of babies screened unnecessarily.
- Subjects
BIRTH weight; GESTATIONAL age; MEDICAL screening; RETINA; RETROLENTAL fibroplasia; MULTIPLE regression analysis; RETROSPECTIVE studies
- Publication
Paediatrics & Child Health (1205-7088), 2020, Vol 25, Issue 7, p455
- ISSN
1205-7088
- Publication type
Article
- DOI
10.1093/pch/pxz085