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- Title
The Role of Vitamin D in Cancer Prevention.
- Authors
Garland, Cedric F.; Garland, Frank C.; Gorham, Edward D.; Lipkin, Martin; Newmark, Harold; Mohr, Sharif B.; Holick, Michael F.
- Abstract
Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk. The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer Incidence and mortality at low cost, with few or no adverse effects.
- Subjects
VITAMIN D; HUMAN skin color; CANCER risk factors; VITAMIN D deficiency; PUBLIC health
- Publication
American Journal of Public Health, 2006, Vol 96, Issue 2, p252
- ISSN
0090-0036
- Publication type
Article
- DOI
10.2105/AJPH.2004.045260